Cytotoxicity study of dimethylisatin and its heterocyclic derivatives

Authors

  • Mohammad Mamun Hossain Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Nazrul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Rahat Khan Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342
  • Md. Rabiul Islam Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342

DOI:

https://doi.org/10.3329/bjp.v2i2.572

Keywords:

Cytotoxicity, Dimethylisatin, Thiazol-triazinoindole

Abstract

Isatin derivatives are bioactive molecules. To study the cytotoxicity and eventually the anticancer activities against cancer cell lines, a series of dimethyl-substitituted isatin derivatives (4-8) starting from isatin thiosemicarbazones (3) had been synthesized in high yields. Investigation of the cytotoxicity of these compounds was carried out against brine shrimp by lethality bioassay. The present study shows that compounds 4, 5, 6 and 8/ with heterocyclic moiety had pronounced cytotoxicity whereas 7, 7/ and 8 were moderately active. It is remarkable that the substituent, X = -OCH3 has greater activity than the bromine atom in this series.

 

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How to Cite

Hossain, M. M., N. Islam, R. Khan, and M. R. Islam. “Cytotoxicity Study of Dimethylisatin and Its Heterocyclic Derivatives”. Bangladesh Journal of Pharmacology, vol. 2, no. 2, June 2007, pp. 66-70, doi:10.3329/bjp.v2i2.572.

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Research Articles