Cardioprotective effect of amlodipine in oxidative stress induced by experimental myocardial infarction in rats


  • Sudhira Begum Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000
  • Nargis Akhter Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000



Amlodipine, Aspertate aminotransferase, Cardioprotection, Lactate dehydrogenase, Malondialdehyde


The present study investigated whether the administration of amlodipine ameliorates oxidative stress induced by experimental myocardial infarction in rats. Adrenaline was administered and myocardial damage was evaluated biochemically [significantly increased serum aspertate aminotransferase (AST), lactate dehydrogenase (LDH) and malondialdehyde (MDA) levels of myocardial tissue] and histologically (morphological changes of myocardium). Amlodipine was administered as pretreatment for 14 days in adrenaline treated rats. Statistically significant amelioration in all the biochemical parameters supported by significantly improved myocardial morphology was observed in amlodipine pretreatment. It was concluded that amlodipine afforded cardioprotection by reducing oxidative stress induced in experimental myocardial infarction of catecholamine assault.


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How to Cite

Begum, S., and N. Akhter. “Cardioprotective Effect of Amlodipine in Oxidative Stress Induced by Experimental Myocardial Infarction in Rats”. Bangladesh Journal of Pharmacology, vol. 2, no. 2, June 2007, pp. 55-60, doi:10.3329/bjp.v2i2.570.



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