Ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate improve mitochondrial function under condition of cerebral ischemia in rat

  • Pozdnyakov I. Dmitry Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).
  • Nygaryan A. Syranusch Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).
  • Voronkov V. Andrey Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).
  • Anastasya Sosnovskaya Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).
  • Cherechkova I. Elisaveta Department of Pharmacology with Course of Clinical Pharmacology, Pyatigorsk Medical and Pharmaceutical Institute, A Branch Volgograd State Medical University, Pyatigorsk, Russia (357532, Pyatigorsk, av. Kalinina 11).
Keywords: Acetylcysteine, Cerebral ischemia, Choline alphoscerate, Ethylmethylhydroxypyridine, Mitochondrial function, Rat

Abstract

The study was devoted to see the effect of ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate on the mitochondrial function under condition of experimental cerebral ischemia in rat. An integrated approach was used with the assessment of changes in the respirometric and antiapoptotic functions of mitochondria. It was found that the application of the objects under study contributed to a decrease in the intensity of glycolysis and the restoration of aerobic glucose metabolism with an increase in ATP synthesis, as well as a decrease in the dissociation of reactions in mitochondrial complexes I, II, IV and V. In addition, the introduction of the studied drugs reduced the intensity of caspase-dependent and caspase-independent apoptosis reactions, which, together with the restoration of mitochondrial respiratory function, contributed to the decrease in the size of the necrosis zone of the brain.

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Published
2019-08-28
How to Cite
Dmitry, P., N. Syranusch, V. Andrey, A. Sosnovskaya, and C. Elisaveta. “Ethylmethylhydroxypyridine Succinate, Acetylcysteine and Choline Alphoscerate Improve Mitochondrial Function under Condition of Cerebral Ischemia in Rat”. Bangladesh Journal of Pharmacology, Vol. 14, no. 3, Aug. 2019, pp. 152-8, doi:10.3329/bjp.v14i3.40977.
Section
Research Articles