Cardioprotective effect of Erythrina stricta leaves on isoproterenol-induced myocardial infarction in rat

Authors

  • Asokkumar Kuppusamy Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Subhadradevi Varadharajan Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Christy Josey Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Honey John Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Daphne Sherin Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Divia Chirakkan Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu
  • Gokul Athiyappan Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu

DOI:

https://doi.org/10.3329/bjp.v5i1.3809

Keywords:

Cardioprotective, Erythrina stricta, Lipid peroxidation, Myocardial infarction

Abstract

The cardioprotective activity of Erythrina stricta leaves against isoproterenol-induced myocardial infarction was studied. Wistar albino rats were pretreated with leaf extract (200 mg/kg) daily for 28 days. After treatment, isoproterenol (8.5 mg/kg body weight, orally) was injected to rats at an interval of 24 hours for two days to induce myocardial injury. Cardioprotection was investigated by estimating the activities of serum aminotransferase, lactate dehydrogenase  and creatinine kinase. Anti-oxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and thiobarbituric acid reactive substances were determined. The activities of serum marker enzymes were increased significantly (p<0.05) in isoproterenol-induced rats. E. stricta leaf extract showed a decrease in serum enzyme levels and increase of antioxidant status. The results were confirmed by histopathological evidences. The present study concludes that E. stricta leaf extract has a prophylactic value in myocardial infarction.

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Author Biography

Asokkumar Kuppusamy, Department of Pharmacology, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641 044, Tamil Nadu

References

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Additional Files

Published

2010-03-02

How to Cite

Kuppusamy, A., S. Varadharajan, C. Josey, H. John, D. Sherin, D. Chirakkan, and G. Athiyappan. “Cardioprotective Effect of Erythrina Stricta Leaves on Isoproterenol-Induced Myocardial Infarction in Rat”. Bangladesh Journal of Pharmacology, vol. 5, no. 1, Mar. 2010, pp. 1-4, doi:10.3329/bjp.v5i1.3809.

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Research Articles