In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

  • Amel Bouaziz Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria. https://orcid.org/0000-0002-3265-6659
  • Seddik Khennouf Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria.
  • Musa Abu Zarga Department of chemistry, Faculty of science, the University of Jordan, Amman, Jordan.
  • Shtaywy Abdalla Department of Biology, Faculty of Science, the University of Jordan, Amman, Jordan
Keywords: Anti-oxidant, Diuretic, Hypotensive, In vitro, Origanum glandulosum, Rat

Abstract

The objective of this study was to evaluate the in vitro anti-oxidant, hypo-tensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3-methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents.

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Author Biographies

Seddik Khennouf, Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria.
Laboratory of Phytotherapy Applied to Chronic Diseases, Department of Biology and Animal Physiology, Faculty of Nature and Life Sciences, University Setif 1, Setif, 19000, Algeria.
Musa Abu Zarga, Department of chemistry, Faculty of science, the University of Jordan, Amman, Jordan.

 Natural products laboratory, Department of chemistry, Faculty of science, the University of Jordan, Amman, Jordan.

Shtaywy Abdalla, Department of Biology, Faculty of Science, the University of Jordan, Amman, Jordan

Animal & Human Physiology Laboratory, Department of Biology, Faculty of Science, the University of Jordan, Amman, Jordan

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Published
2019-01-20
How to Cite
Bouaziz, A., S. Khennouf, M. Abu Zarga, and S. Abdalla. “In Vitro Anti-Oxidant, Hypotensive and Diuretic Activities of Origanum Glandulosum in Rat”. Bangladesh Journal of Pharmacology, Vol. 14, no. 1, Jan. 2019, pp. 17-25, doi:10.3329/bjp.v14i1.38089.
Section
Research Articles