Study of analgesic activity of ethanol extract of Phlogacanthus thyrsiflorus on experimental animal models

  • Apurba Mukherjee Department of Pharmacology, Assam Medical College, Dibrugarh, Assam 786 002
  • Meghali Chaliha Department of Pharmacology, Assam Medical College, Dibrugarh, Assam 786 002
  • Swarnamoni Das Department of Pharmacology, Assam Medical College, Dibrugarh, Assam 786 002
Keywords: Analgesic, Phlogocanthus thyrsiflorus, Tail flick, Writhing

Abstract

The aim of the study was to evaluate the central and peripheral analgesic action of Phlogacanthus thyrsiflorus in experimental animal models. The extract was prepared by percolation method and acute oral toxicity testing was performed as per  OECD guidelines. Analgesic activity was assessed by tail flick method (for central action) and glacial acetic acid-induced writhing test (for peripheral action). Leaves extract (500 mg/kg, p.o.) and aspirin (100 mg/kg) showed significant peripheral analgesic activity (p<0.05). Leaves extract (500 mg/kg, p.o.) and pethidine (50 mg/kg, i.p.) also showed significant central analgesic activity (p<0.05). Naloxone (1 mg/kg, s.c.) was used to find the mechanism of central analgesic action. Some partial agonistic activity for the opioid receptors seems to be probable mechanism of action.

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Author Biography

Apurba Mukherjee, Department of Pharmacology, Assam Medical College, Dibrugarh, Assam 786 002

Postgraduate Student

References

DArmour FE, Smith DL. A method for determining loss of pain sensation . J Pharmacol Exp Ther. 1941; 72: 74-79.

Fields HL, Martin JB. Pain pathophysiology and management. In: Harrisons Principles of internal medicine. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL (eds). 17th ed. New York, McGraw Hill, 2008, pp 81-86.

Ghosh MN. Guide to drug doses in laboratory animals. In: Fundamentals of experimental pharmacology. 4th ed. Kolkata , India, Ghosh and others, 2008a, pp 243-56.

Ghosh MN. Toxicity studies. In: Fundamentals of experimental pharmacology. 4th ed. Kolkata, India, Ghosh and others, 2008b, pp 176-83.

Kalita D, Bora RL. Some folk medicines from Lakhimpur district, Assam. Indian J Traditional Knowledge. 2008; 7: 414-16.

Kanodia L, Das S. A comparative study of analgesic property of whole plant and fruit extracts of Frageria vesca in experimental animal models. Bangladesh J Pharmacol. 2009; 4: 35-38.

Khanikar G. In: Sahajlavya Bandarabar Gun. 7th ed (Revised). Guwahati, India, Puthitirtha Prakashan, 2005, p 34.

Koneri R, Balaram R. Antidiabetic mechanisms of saponins of Momordica cymbalaria. Pharmacog Mag. 2008; 4: 197-206.

Nairn JG. Solutions, emulsions, suspensions and extracts. In: Remington: the science and practice of pharmacy. Gennaro A, Marderosian AD, Hanson GR, Medwick T, Popovich NG, Schnaare RL et al (eds). 20th ed. Philadelphia, Lippincott Williams and Wilkins, 2000, pp 721-52.

OECD. OECD Guidelines for Testing of Chemicals [internet]. France: OECD Publishing; 2006. Section 4, Health effects: Test No. 425: Acute oral toxicity: Up and down procedure.

Patwari B. In: A glossary of medicinal plants of Assam and Meghalaya. 1st ed. Guwahati, India. M.N. Printers, 1992, p 98.

Rao KV. Multiple comparision test procedures. In: Biostatistics. Rao KV, Balakrishnan N (eds.).1st Ed. New Delhi, India, Jaypee Brothers Medical Publishers, 1999, pp 273-78.

Shreedhara CS, Vaidya VP, Vagdevi HM, Latha KP, Muralikrishna KS, Krupanidhi AM. Screening of Bauhinia purpurea Linn. for analgesics and anti-inflammatory activities. Indian J Pharmacol. 2009; 41: 75-79.

Tripathi KD. Opioid analgesics and antagonists. In: Essentials of medical pharmacology. 6th ed. New Delhi, India, Jaypee Brothers Medical Publishers (P) Ltd, 2008, pp 453-74.

Witkin LB, Hebner CF, Gaddi F, OKeefe E, Spilaletta P, Plummer AJ. Pharmacology of 2-amino-indane hydrochloride (SU-8629). A potent non-narcotic analgesic. J Pharmacol Exp Ther. 1961; 133: 400-08.

Published
2009-12-15
How to Cite
Mukherjee, A., M. Chaliha, and S. Das. “Study of Analgesic Activity of Ethanol Extract of Phlogacanthus Thyrsiflorus on Experimental Animal Models”. Bangladesh Journal of Pharmacology, Vol. 4, no. 2, Dec. 2009, pp. 147-9, doi:10.3329/bjp.v4i2.3808.
Section
Research Articles