Anti-adipogenic effect of mastoparan B analogue peptide on 3T3-L1 preadipocytes

Authors

DOI:

https://doi.org/10.3329/bjp.v13i4.37351

Keywords:

Mastoparan B, Venom, Vespa basalis

Abstract

Mastoparan B (MP-B), a cationic tetradecapeptide isolated from the venom of the Vespa basalis, exhibits cardiovascular effects, local edema and antibacterial activity. In this study, the anti-adipogenic effect of an MP-B analogue and its mechanism of action in 3T3-L1 preadipocytes were studied. The MP-B analogue (MP-B12) inhibited preadipocyte differentiation and decreased the expression of adipogenic transcription factors, including CCAAT/enhancer binding protein-alpha (C/EBPα), nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) and sterol regulatory element-binding protein-1 (SREBP-1). Moreover, MP-B12 regulated the phosphorylation of Akt and glycogen synthase kinase-3 beta (GSK-3β), both of which play a role in preadipocyte differentiation, in which insulin and certain growth factors stimulated adipogenesis. This study demonstrates that MP-B12 inhibits preadipocyte differentiation and the accumulation of lipid droplets in 3T3-L1 preadipocytes and could potentially be used to treat obesity.

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Author Biography

Gun Do Kim, Depratment of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Korea

Professor

Published

2018-11-13

How to Cite

Kim, J. H., M. J. Jo, H. J. Go, N. G. Park, and G. D. Kim. “Anti-Adipogenic Effect of Mastoparan B Analogue Peptide on 3T3-L1 Preadipocytes”. Bangladesh Journal of Pharmacology, vol. 13, no. 4, Nov. 2018, pp. 333-9, doi:10.3329/bjp.v13i4.37351.

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Section

Research Articles