Harmine and its derivatives: Biological activities and therapeutic potential in human diseases

Authors

  • Maria Javeed Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan
  • Azhar Rasul Cell and Molecular Biology Lab, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan. http://orcid.org/0000-0001-9669-7364
  • Ghulam Hussain Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan
  • Farhat Jabeen Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan
  • Bilal Rasool Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan
  • Ammara Riaz Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan
  • Ghazala Kaukab Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan
  • Muhammad Ali Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan

DOI:

https://doi.org/10.3329/bjp.v13i3.34990

Abstract

This review article aims to provide an update on the sources, pharmaco-logical and biological profile of a β-carboline alkaloid, harmine which is a major bioactive component of various plants mainly Peganum harmala. Harmine’s wide range of pharmacological properties has been well-documented as anti-cancer, anti-inflammatory, anti-oxidant, neuroprotective, anti-depressant, and antimicrobial. Although reported data suggests a multifunctional pharmacological role of harmine but farther experimentation on its molecular mechanism of action, synthetic chemistry approaches, and preclinical studies are yet obligatory to fully uncover its pharmacological efficacy.

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Author Biographies

Azhar Rasul, Cell and Molecular Biology Lab, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan.

Assistant Professor

Ghulam Hussain, Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan

Assistant Professor

Farhat Jabeen, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan

Professor and Chairman

Bilal Rasool, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan

Assistant Professor

Ammara Riaz, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan

PhD Scholar

Ghazala Kaukab, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan

Assistant Professor

Muhammad Ali, Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan

Professor and Vice Chancellor

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Published

2018-07-07

How to Cite

Javeed, M., A. Rasul, G. Hussain, F. Jabeen, B. Rasool, A. Riaz, G. Kaukab, and M. Ali. “Harmine and Its Derivatives: Biological Activities and Therapeutic Potential in Human Diseases”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, July 2018, pp. 203-1, doi:10.3329/bjp.v13i3.34990.

Issue

Section

Mini Review