Labisia pumila improves wound healing process in ovariectomized rat model

Authors

  • Shihab Uddin Ahmad Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur http://orcid.org/0000-0002-7441-4471
  • Ahmad Nazrun Shuid Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur http://orcid.org/0000-0003-3526-990X
  • Isa Naina Mohamed Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur http://orcid.org/0000-0001-8891-2423

DOI:

https://doi.org/10.3329/bjp.v13i1.34473

Keywords:

Labisia pumila, Ovariectomized, Rat, Wound healing

Abstract

The purpose of this study was to determine the wound healing effect of Labisia pumila in the ovariectomized rat model. Ninety-nine Sprague Dawley female rats equally divided into nine groups; where five were control groups, and four were treated groups. The dressing was changed daily, starting from the wound induction until complete healing. The percentage of wound contraction was measured on day 0, 2, 5, 8, 9, 10, 11, 12 and 13. Three rats were sacrificed from each group on day 2, 5 and 8 respectively for evaluating of histological assessments. Wounds dressed with extract showed considerable healing and significantly healed faster compared to all control groups (p<0.05). Moreover, histological analysis revealed remarkable reduction in the scar width correlated with the enhanced collagen content and fibroblast cells, accompanied by a reduction of inflammatory cells in the granulation tissues. In conclusion, L. pumila may promote wound healing in postmenopausal rat model.

Video Clip of Methodology:

Ovariectomy and punch biopsy: 3 min 11 sec:   Click to Watch

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Author Biographies

Shihab Uddin Ahmad, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur

PhD student

Ahmad Nazrun Shuid, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur

Professor

Isa Naina Mohamed, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur

Associate Professor

Published

2018-03-30

How to Cite

Ahmad, S. U., A. N. Shuid, and I. N. Mohamed. “Labisia Pumila Improves Wound Healing Process in Ovariectomized Rat Model”. Bangladesh Journal of Pharmacology, vol. 13, no. 1, Mar. 2018, pp. 106-13, doi:10.3329/bjp.v13i1.34473.

Issue

Section

Research Articles