A new class of potential antidiabetic acetohydrazides: Synthesis, in vivo antidiabetic activity and molecular docking studies

Authors

  • Mubeen Arif Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Furukh Jabeen Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Aamer Saeed Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Irfan Zia Qureshi Department of Chemistry, Quaid-I-Azam University, Islamabad 45320
  • Nadia Mushtaq Department of Chemistry, Quaid-I-Azam University, Islamabad 45320

DOI:

https://doi.org/10.3329/bjp.v12i3.31428

Keywords:

Tetrazolopyridine-acetohydrazide, diabetes mellitus, antidiabetic agent, plasma glucose, glibenclamide.

Abstract

Two new pharmacologically active series of tetrazolopyridine-acetohydrazide conjugates [9 (a-n), 10 (a-n)] were synthesized by reacting a variety of suitably substituted benzaldehydes and isomeric 2-(5-(pyridin-3/4-yl)-2H-tetrazol-2-yl)acetohydrazides (7, 8). The synthesized compounds were analyzed through FTIR, 1H NMR, 13C NMR and elemental techniques. These acetohydrazides were screened for their in vivo antidiabetic activity and molecular docking studies. An excellent agreement was obtained as the best docked poses show-ed important binding features mostly based on interactions due to an oxygen atom and aromatic moieties of the series. The compounds 9a, 9c and 10l were found to be the most active in lowering blood glucose, having the potential of being good antidiabetic agents.

Video Clip of Methodology:

Synthesis of 3/4-(2H-tetrazole-5-yl)pyridine: 1 min 57 sec   Full Screen   Alternate

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Author Biography

Aamer Saeed, Department of Chemistry, Quaid-I-Azam University, Islamabad 45320

Professor of chemistry

Published

2017-09-05

How to Cite

Arif, M., F. Jabeen, A. Saeed, I. Z. Qureshi, and N. Mushtaq. “A New Class of Potential Antidiabetic Acetohydrazides: Synthesis, in Vivo Antidiabetic Activity and Molecular Docking Studies”. Bangladesh Journal of Pharmacology, vol. 12, no. 3, Sept. 2017, pp. 319-32, doi:10.3329/bjp.v12i3.31428.

Issue

Section

Research Articles