Anti-cancer effect of Atractylodes macrocephala extract by double induction of apoptotic and autophagic cell death in head and neck cancer cells

Authors

  • Ni Kou Department of Oral Maxillofacial Surgery, College of Stomaology, Dalian Medical University, Dalian 116044 http://orcid.org/0000-0003-3622-4228
  • Hyejoung Cho Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186 http://orcid.org/0000-0002-8038-4651
  • Hye-Eun Kim Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186 http://orcid.org/0000-0003-0401-7179
  • Qiaochu Sun Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186 http://orcid.org/0000-0002-0713-9000
  • Kyuhyeon Ahn Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186 http://orcid.org/0000-0002-9544-3159
  • Hyeongjoon Ji Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186 http://orcid.org/0000-0001-9003-7090
  • Hongran Choi Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186 http://orcid.org/0000-0003-2494-8632
  • Okjoon Kim Department of Oral Pathology, Dental Science Research Institute and Medical Research Center for Biomineralization Disorders, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186 http://orcid.org/0000-0002-6347-1411

DOI:

https://doi.org/10.3329/bjp.v12i2.31238

Keywords:

Anti-cancer, Apoptosis, Atractylodes macrocephala, Autophagy, Cell death, Head and neck cancer cell

Abstract

The apoptosis resistance restricts the efficacy of traditional therapies of head and neck squamous cell carcinoma (HNSCC). To overcome this problem, Atractylodes macrocephala, a traditional Korean and Chinese herbal medicine, has been used in clinical practice. In the present study, the anticancer effect of A. macrocephala extract was investigated and its underlying mechanisms using head and neck cancer KB cell line. The extract-induced cytotoxicity was mediated by autophagic cell death as well as apoptosis in HNSCC cells though extrinsic apoptotic pathway and the Akt/mTOR autophagic pathway. This study suggests that A. macrocephala extracts can be a potential drug to overcome side effects and susceptibility for head and neck carcinoma by double induction of apoptosis and autophagy.

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Published

2017-04-25

How to Cite

Kou, N., H. Cho, H.-E. Kim, Q. Sun, K. Ahn, H. Ji, H. Choi, and O. Kim. “Anti-Cancer Effect of Atractylodes Macrocephala Extract by Double Induction of Apoptotic and Autophagic Cell Death in Head and Neck Cancer Cells”. Bangladesh Journal of Pharmacology, vol. 12, no. 2, Apr. 2017, pp. 140-6, doi:10.3329/bjp.v12i2.31238.

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Section

Research Articles