Diuretic activity of aqueous extract and smoothie preparation of Verbesina crocata in rat

Authors

  • Anuar Gómez Salazar Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico http://orcid.org/0000-0001-9633-6542
  • Saudy Saret Pérez Pablo Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico http://orcid.org/0000-0001-5745-6437
  • María Mirian Carmona Estévez Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico http://orcid.org/0000-0001-9945-8545
  • María Estela Camargo Meléndez Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico http://orcid.org/0000-0002-6052-0281

DOI:

https://doi.org/10.3329/bjp.v13i3.27584

Keywords:

Diuretic, Verbesina crocata

Abstract

The aim of this study was to evaluate the diuretic activity of aqueous extract of Verbesina crocata at different doses in rat. The aqueous extract (100 and 400 mg/kg for decoction; 200 and 400 mg/kg for smoothie form), furosemide (4 mg/kg and vehicle were administered per os to rat. After 6 hours in metabolic cages, the urinary flow, glomerular filtration rate and electrolyte balance (Na+ and K+) were assessed. All doses produced an increment of urinary flow and Na+/K+ excretion. Glomerular filtration rate was incremented only on smoothie form at 400 mg/kg. These findings provide a basis explaining the traditional folk medicine use of this plant as a diuretic agent.

Video Clip of Methodology:

Method for diuretic activity: 1 min 37 sec    Click to watch   

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Author Biographies

Anuar Gómez Salazar, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico

PhD student

Saudy Saret Pérez Pablo, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico

Professor and Head Group researcher

María Mirian Carmona Estévez, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico

Professor and Head Group researcher

María Estela Camargo Meléndez, Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN), Mexico City 07738, Mexico

Professor and Head Group researcher

Verbesina crocata

Published

2018-08-07

How to Cite

Salazar, A. G., S. S. P. Pablo, M. M. C. Estévez, and M. E. C. Meléndez. “Diuretic Activity of Aqueous Extract and Smoothie Preparation of Verbesina Crocata in Rat”. Bangladesh Journal of Pharmacology, vol. 13, no. 3, Aug. 2018, pp. 236-40, doi:10.3329/bjp.v13i3.27584.

Issue

Section

Research Articles