Anti-aging activity of Radix polygoni multiflori preparata in aging mice model induced by D-galactose by bioassay method

Authors

  • Jiang Yan Huo School of Chinese Materia Medica, Guangdong Pharmaceutical University, Key Laboratory of State Administration of TCM for Digital Quality Evaluation Technology of Traditional Chinese Medicine, Guangdong Academies TCM Quality Engineering Technology Research Center, Guangzhou 510006
  • Hong Chao Shen School of Chinese Materia Medica, Guangdong Pharmaceutical University, Key Laboratory of State Administration of TCM for Digital Quality Evaluation Technology of Traditional Chinese Medicine, Guangdong Academies TCM Quality Engineering Technology Research Center, Guangzhou 510006
  • Shu Mei Wang School of Chinese Materia Medica, Guangdong Pharmaceutical University, Key Laboratory of State Administration of TCM for Digital Quality Evaluation Technology of Traditional Chinese Medicine, Guangdong Academies TCM Quality Engineering Technology Research Center, Guangzhou 510006
  • Zhan Ke Chen Henan University of Traditional Chinese Medicine, Zhengzhou 450008
  • Sheng Wang Liang School of Chinese Materia Medica, Guangdong Pharmaceutical University, Key Laboratory of State Administration of TCM for Digital Quality Evaluation Technology of Traditional Chinese Medicine, Guangdong Academies TCM Quality Engineering Technology Research Center, Guangzhou 510006

DOI:

https://doi.org/10.3329/bjp.v11iS1.27010

Keywords:

Anti-aging, D-galactose, Mice, Radix polygoni multiflori

Abstract

Anti-aging effect of Radix polygoni multiflori preparata in aging mice model was examined by bioassay method and explore new model of quality control of Traditional Chinese Medicine. Model of aging mice induced by D-galactose were used. The activity of senescence associated molecular markers such as superoxide dismutase, malondialdehyde and glutathione peroxidase in serum or homogenate were determined to evaluate the anti-aging activity. The results showed that the polysaccharide content in the 0.4, 0.8 g/mL decoction were 80.1, 160.2 mg/mL respectively. The HPLC results showed that stibene glucoside content in the 0.4 and 0.8 g/mL decoction were 404 and 808 mg/mL respectively. Experimental results showed that 10 week-old mice were the most sensitive to SOD activity in homogenate. In conclusion, Radix polygoni multiflori preparata has anti-aging effect probably by removing ROS.

 

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Published

2016-03-11

How to Cite

Huo, J. Y., H. C. Shen, S. M. Wang, Z. K. Chen, and S. W. Liang. “Anti-Aging Activity of Radix Polygoni Multiflori Preparata in Aging Mice Model Induced by D-Galactose by Bioassay Method”. Bangladesh Journal of Pharmacology, vol. 11, no. S1, Mar. 2016, pp. S168-S176, doi:10.3329/bjp.v11iS1.27010.

Issue

Section

Research Articles