Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaf extract

Authors

  • Maroua Akacha Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage
  • Karima Lahbib Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage
  • Mejda Daami-Remadi UR13AGR09, Integrated Horticultural Production in the Tunisian Centre East Regional Center of Research on Horticulture and Organic Agriculture of Chott-Mariem, Sousse University, 4042, Chott-Mariem
  • Néziha Ghanem Boughanmi Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage

DOI:

https://doi.org/10.3329/bjp.v11i3.27000

Keywords:

Antibacterial, Antifungal, Anti-inflammatory, Melia azedarach

Abstract

The aim of the present study is to examine the antibacterial, antifungal and anti-inflammatory activities of the ethanolic leaf extract of Melia azedarach. It was tested in vitro for its antibacterial and antifungal activities against E. coli (ATCC 8739), Enterococcus faecalis (Ec P07) and Bacillus subtilis (Bs) bacteria as well as against pathogenic fungi (Alternaria alternate, Fusarium solani, Fusarium oxysporum sp. melonis, F. oxysporum f. sp. lycopersici, F. sambucinum and Botrytis cinerea) with different techniques similtaneously with anti-inflammatory activity with carageaneen method. All tested concentrations of M. azedarach extract showed significant antibacterial and antifungal activities with low IC50 compared to ethanol 95% and a high anti-inflammatory activity compared with indomethacin as drug. Our investigation pointed that M. azedarach could be considered as a good medicinal agent.

Video Clip of Methodology:

Anti-inflammatory effect: 3 min 03 sec   Click to watch 

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Author Biography

Karima Lahbib, Laboratory of environment Biosurveillance, Department of Biology, Faculty of Sciences of Bizerte, Zarzouna, 7021, University of Cartage


Published

2016-07-05

How to Cite

Akacha, M., K. Lahbib, M. Daami-Remadi, and N. G. Boughanmi. “Antibacterial, Antifungal and Anti-Inflammatory Activities of Melia Azedarach Ethanolic Leaf Extract”. Bangladesh Journal of Pharmacology, vol. 11, no. 3, July 2016, pp. 666-74, doi:10.3329/bjp.v11i3.27000.

Issue

Section

Research Articles