Nuclear shuttling of Y Box binding protein-1, its clinical relevance in cancer and as a therapeutic target

Authors

DOI:

https://doi.org/10.3329/bjp.v11i2.26759

Keywords:

Cancer, Nuclear shuttling, Y-box binding protein 1

Abstract

Y-box binding protein 1 (YB-1) is an imperative biomarker for the clinical out-come of cancer patients. An overexpression of YB-1 in cancerous and adjoining tissues is an indication of aggressiveness and advanced stages. In normal resting cells, YB-1 is localized in cytoplasm while in stress conditions like cancer, nuclear shuttling of YB-1 takes place. In this review, the clinical importance of YB-1 in different cancers and the mechanism behind YB-1 nuclear shuttling have been discussed in detail. Targeted chemotherapies or molecularly targeted drugs of great importance can target and block specific molecules implicated in tumor growth and progression. YB-1 has been considered as a bonafide oncogene and accumulating evidences show the therapeutic importance of YB-1. Therapeutic strategies targeting YB-1 may improve the survival rate in cancer patients. This review extensively discusses the therapeutic importance of YB-1.

 

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Author Biographies

Vinoth Prasanna Gunasekaran, Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, Tamilnadu

Research Scholar

Kumari Nishi, Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, Tamilnadu

Postdoctoral fellow

Vilwanathan Ravikumar, Department of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu

Assistant Professor

Ganeshan Mathan, Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, Tamilnadu

Assistant Professor

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2016-04-30

How to Cite

Gunasekaran, V. P., K. Nishi, V. Ravikumar, and G. Mathan. “Nuclear Shuttling of Y Box Binding Protein-1, Its Clinical Relevance in Cancer and As a Therapeutic Target”. Bangladesh Journal of Pharmacology, vol. 11, no. 2, Apr. 2016, pp. 501-24, doi:10.3329/bjp.v11i2.26759.

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