Antidepressant activity of Nyctanthes arbor-tristis in mice

Authors

DOI:

https://doi.org/10.3329/bjp.v11i3.26682

Keywords:

Anti-depressant, Mouse, Nyctanthes arbor-tristis

Abstract

The present study assesses the protective effect of Nyctanthes arbor-tristis (Nyctaginaceae) extracts and in combination with fluoxetine on stress-induced depression in mice. Leaves were extracted using different solvents (petroleum ether, chloroform and hydroethanol) and administered orally for 14 days. These extracts showed significant improvement in the mobility percentage but among these, hydroethanol extract showed better protective effect from day 1 to 14 in both forced swimming and tail suspension test model. Hydroethanol (100 mg/kg) and chloroform (100 mg/kg) extracts with fluoxetine showed synergistic effect when compared with fluoxetine treated group (10 mg/kg) alone at day 7 and 14. Among monoamine levels only hydroethanol extract (400 mg/kg) restored the 5-HT level near to level of fluoxetine-treated group. Hydroethanol extracts with two higher doses showed significant decrease in glucose and triglycerides levels. Clinically, it may useful as antidepressant drug.          

Video Clip of Methodology:

Tail suspension test: 5 min 57 sec   Click to watch 

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Author Biography

Sumeet Gupta, Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana (Ambala), Haryana

Professor and Head

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Published

2016-06-19

How to Cite

Gupta, S., P. Kashyap, M. Asad, I. Chattopadhyaya, and R. Dahiya. “Antidepressant Activity of Nyctanthes Arbor-Tristis in Mice”. Bangladesh Journal of Pharmacology, vol. 11, no. 3, June 2016, pp. 634-45, doi:10.3329/bjp.v11i3.26682.

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Section

Research Articles