Antiepileptic potential of Silybum marianum seeds in pentylenetetrazol-induced kindled mice

Authors

  • Huma Waqar Institute of Pharmacy, Lahore College for Women University, Lahore 54000
  • Humaira Majeed Khan Institute of Pharmacy, Lahore College for Women University, Lahore 54000
  • Aftab Ahmad Anjum Department of Microbiology, University of Veterinary and Animal Sciences, Lahore http://orcid.org/0000-0001-8262-8720

DOI:

https://doi.org/10.3329/bjp.v11i3.26181

Keywords:

Epilepsy, Kindling, Pentylenetetrazol, Silybum marianum

Abstract

Epilepsy is an abnormality of nervous system showing seizures. Despite, the known antiepileptic activity of plants possessing antioxidant properties, Silybum marianum has not been studied yet. Therefore, present experiment was planned to evaluate antiepileptic potential of S. marianum (100, 200 and 300 mg/kg) seeds ethanol extract in pentylenetetrazol-induced kindled mice (n = 30). S. marianum seed extract (300 mg/kg) provided significant protection against pentylenetetrazol-induced convulsions (seizure intensity, latency and lethality) comparable with reference drug (valproic acid). Furthermore, 300 mg/kg/day dose was effective to prevent oxidative stress causing significant decrease in the lipid peroxidation (1.4 ± 0.4 nmol/mg protein) and increased superoxide dismutase (0.4 ± 0.1 µmol/mg protein) and catalase activity (4.7 ± 0.8 U/mL) of mice brain as compared to induced untreated group (p<0.05). It was concluded that antiepileptic activity of S. marianum seeds was due to its antioxidant property.

Video Clip of Methodology:

Experimental induction of seizures: 10 min 4 sec   Click to watch

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Author Biography

Aftab Ahmad Anjum, Department of Microbiology, University of Veterinary and Animal Sciences, Lahore

Professor

Published

2016-06-12

How to Cite

Waqar, H., H. M. Khan, and A. A. Anjum. “Antiepileptic Potential of Silybum Marianum Seeds in Pentylenetetrazol-Induced Kindled Mice”. Bangladesh Journal of Pharmacology, vol. 11, no. 3, June 2016, pp. 603-9, doi:10.3329/bjp.v11i3.26181.

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Section

Research Articles