Non-invasive positive pressure ventilation offers greater improvement in COPD-related respiratory failure when combined with naloxone

Authors

  • Long Zhang Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Wei Zhao Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Qinfu Xu Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Yumiao Zhao Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Junjie Zhao Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Yin-long Ren Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Yu-jing Liu Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Jing Li Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province
  • Ai-Guo Xu Department of Respiration and Intensive, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province

DOI:

https://doi.org/10.3329/bjp.v11i2.25469

Keywords:

Clinical trial, COPD, Naloxone, Respiratory failure, Ventilation

Abstract

To improve efficacy of non-invasive positive pressure ventilation (NPPV), this study investigated the combination of NPPV with naloxone in COPD patients with respiratory failure. One hundred four patients with COPD-related respiratory failure were enrolled prospectively and randomly divided into a control group treated with NPPV alone (n = 52) and an observation group treated with NPPV combined with 4.0 mg naloxone by continuous infusion (n = 52). At 3 and 5 days after the start of treatment, the respiratory mechanics, pulmonary function, and oxygen metabolism parameters were significantly improved in the NPPV + naloxone group compared to the NPPV alone group (p<0.05). Further, the improvements in the NPPV plus naloxone group were greater at day 5 than at day 3 (p<0.05). These findings indicate that non-invasive positive pressure ventilation combined with naloxone can more effectively improve respiratory mechanics, pulmonary function and oxygen metabolism of COPD patients with respiratory failure than NPPV alone, offering a new treatment approach.

 

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Additional Files

Published

2016-03-20

How to Cite

Zhang, L., W. Zhao, Q. Xu, Y. Zhao, J. Zhao, Y.- long Ren, Y.- jing Liu, J. Li, and A.-G. Xu. “Non-Invasive Positive Pressure Ventilation Offers Greater Improvement in COPD-Related Respiratory Failure When Combined With Naloxone”. Bangladesh Journal of Pharmacology, vol. 11, no. 2, Mar. 2016, pp. 359-63, doi:10.3329/bjp.v11i2.25469.

Issue

Section

Clinical Trial