Protective effects of paeonol on cardiovascular complications in diabetes mellitus involves modulation of PI3K /Akt-GSK-3β signalling, regulation of protease-activated receptor-1 expressions and down-regulation of inflammatory mediators

Authors

  • Jun Li Department of Cardiology, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000
  • Ze-Qing Xu Department of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000
  • Ling Bao Department of Laboratory, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000
  • Zhi-Cao Li Department of Geriatrics, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000
  • Jia-Xiang Qu Department of Geriatrics, The Second People?s Hospital of Zhuhai, Zhuhai, Guangdong 519000 http://orcid.org/0000-0002-8156-0784

DOI:

https://doi.org/10.3329/bjp.v10i4.24334

Keywords:

Cardiovascular, Diabetes mellitus, Inflammatory mediator, Paeonol, PI3K /Akt-GSK-3? signaling, Protease-activated receptor-1 expression

Abstract

The present study was taken as an effort to assess the effects of paeonol on diabetic cardiomyopathy. Diabetes was induced in separate groups of Sprague-Dawley rats using streptozotocin. Treatment group animals received paeonol (50, 100 or 200 mg/kg body weight/day; orally) 5 weeks after streptozotocin induction for 6 weeks. Paeonol strikingly reduced myocardial apoptosis and improved cardiac function and myocardial architecture. Serum levels of glucose, reactive oxygen species and inflammatory mediators (TNF-α, IL-6 and IL-1β) were significantly reduced with decreased accumulation of collagen in the cardiac tissue. Paeonol modulated p-Akt, glycogen synthase kinase-3β and glycogen synthase, while significantly down-regulated protease-activated receptor-1, caspase-3, TNF-α, NF-κB p65, and p-Iκ-Bα expressions. Paeonol effectively suppressed diabetic cardiomyopathy by improving myocardial function, regulating the inflammatory responses and Akt signalling.

Downloads

Download data is not yet available.
Abstract
1892
Download
689 Read
501

Published

2015-11-04

How to Cite

Li, J., Z.-Q. Xu, L. Bao, Z.-C. Li, and J.-X. Qu. “Protective Effects of Paeonol on Cardiovascular Complications in Diabetes Mellitus Involves Modulation of PI3K /Akt-GSK-3β Signalling, Regulation of Protease-Activated Receptor-1 Expressions and down-Regulation of Inflammatory Mediators”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Nov. 2015, pp. 903-16, doi:10.3329/bjp.v10i4.24334.

Issue

Section

Research Articles