Effects of intravenous arginine on the healing of human skin graft donor sites: A randomized controlled trial

Authors

  • Ke Li Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China http://orcid.org/0000-0001-7638-0714
  • Wei Lin Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
  • Li-Jun Wu Department of Plastic Surgery, The Second Affiliated Hospital of Soochow University, , China
  • Qiang Qi Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
  • Guo Liang Shen Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
  • Jian Jiang Liu Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
  • Wei Xin Chen Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
  • Jun Xu Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
  • Hangen Qian Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
  • Xiao Yu Zhao Department of Plastic and Burn Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

DOI:

https://doi.org/10.3329/bjp.v10i4.23850

Keywords:

Arginine, Healing of human skin graft, Randomized controlled trial

Abstract

We expounded the effect of intravenous arginine on the healing of human skin graft donor sites. This randomized study was double blind and controlled by placebos from October 2012 to May 2015. Nine patients were selected into the arginine group and 10 were selected into the control group. There was no significance in age, weight, BMI, CRP, albumin and total plasma protein in arginine and control groups. Angiogenesis, re-epithelialization and neutrophil influx of wound healing were measured. The concentrations of plasma amino acid were measured to evaluate our intervention. In our study, plasma arginine and ornithine concentrations in arginine group were the highest after arginine-treated at 2 days. Supplementation of intravenous arginine could not affect on healing of human skin graft donor sites, improve angiogenesis, reepithelialization or neutrophil influx in rats.

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Published

2015-09-18

How to Cite

Li, K., W. Lin, L.-J. Wu, Q. Qi, G. L. Shen, J. J. Liu, W. X. Chen, J. Xu, H. Qian, and X. Y. Zhao. “Effects of Intravenous Arginine on the Healing of Human Skin Graft Donor Sites: A Randomized Controlled Trial”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Sept. 2015, pp. 739-44, doi:10.3329/bjp.v10i4.23850.

Issue

Section

Clinical Trial