Tangeretin prevents prostate cancer cell proliferation and induces apoptosis via activation of Notch signalling and regulating the androgen receptor (AR) pathway and the phosphoinositide 3-kinase (PI3k)/Akt/mTOR pathways

Authors

  • Jin-Jin Guo Department of Urology Surgery, Cangzhou Center Hospital, No.16, Xinhua Road, Cangzhou, Hebei 061000
  • Ying-Jie Li Department of Urology Surgery, Cangzhou Center Hospital, No.16, Xinhua Road, Cangzhou, Hebei 061000
  • Lu-Lu Xin Department of Urology Surgery, Cangzhou Center Hospital, No.16, Xinhua Road, Cangzhou, Hebei 061000

DOI:

https://doi.org/10.3329/bjp.v10i4.23699

Keywords:

Androgen receptor, apoptosis, notch signalling, PI3K/Akt/mTOR pathways, prostate cancer, tangeretin

Abstract

Despite advances in conventional therapies, treatment of prostate cancer is still a challenge. The study aims to assess the possible anti-cancer effects of tangeretin, a dietary flavonoid on human prostate cancer cells (DU145, PC3, LNCaP). Tangeretin (25, 50 and 100 µM) significantly inhibited cancer cell viability and induced DNA fragmentation and apoptosis by increasing caspase-3 and pro-apoptotic proteins (Bad and Bax) with reduced anti-apoptotic proteins (Bcl-2 and Bcl-xL) expressions. Significant inhibition of androgen receptor (AR) and prostate specific antigen (PSA) were seen. Dose-dependent inhibition in Notch signal was observed in expression of Notch 1 and Jagged 1 along with PI3/Akt/mTOR signalling pathway. The results suggest that tangeretin inhibited prostate cancer cell proliferation and induced apoptosis via inhibiting critical pathways in cancer development - AR signalling and PI3/Akt/mTOR - Notch signalling pathways.

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Published

2015-11-08

How to Cite

Guo, J.-J., Y.-J. Li, and L.-L. Xin. “Tangeretin Prevents Prostate Cancer Cell Proliferation and Induces Apoptosis via Activation of Notch Signalling and Regulating the Androgen Receptor (AR) Pathway and the Phosphoinositide 3-Kinase (PI3k)/Akt/MTOR Pathways”. Bangladesh Journal of Pharmacology, vol. 10, no. 4, Nov. 2015, pp. 937-4, doi:10.3329/bjp.v10i4.23699.

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Section

Research Articles