Synthesis, spectroscopic studies of novel N-substituted phthalimides and evaluation of their antibacterial, antioxidant, DNA binding and molecular docking studies

Authors

  • Pattan Sirajuddin Nayab Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India
  • Madhusudana Pulaganti Department of Biochemistry, Sri Krishnadevraya University, Ananthapuram 515 003, India
  • Suresh Kumar Chitta Department of Biochemistry, Sri Krishnadevraya University, Ananthapuram 515 003. India
  • Mohammad Oves Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh 202 002, India
  • Rahisuddin . Department of Chemistry, Jamia Millia Islamia, New Delhi 110 025. India http://orcid.org/0000-0002-7139-6976

DOI:

https://doi.org/10.3329/bjp.v10i3.23637

Keywords:

Antibacterial, Ct-DNA binding, N-Substituted phthalimide, Molecular modeling

Abstract

A new series of N-substituted phthalimide derivatives were prepared by condensation of appropriate amount of n-amino tetrachlorophthalimide with respective aldehyde in glacial acetic acid. The structural investigation of the synthesized compounds was done by spectroscopic methods (UV-Vis., IR, 1H and 13C NMR) and elemental analysis. The antibacterial screening of these compounds was performed against Escherichia coli and Staphylococcus mutans. The synthesized compounds were evaluated for their antioxidant potential using 2,2-diphenyl-1-picrylhydrazyl (DPPH) as a scavenging agent. The interaction ability of most promising compounds (3a and 3b) with native calf thymus DNA (Ct-DNA) was also studied by means of UV-Vis., circular dichroism (CD), viscosity measurements and thermal studies. The intrinsic binding constants (Kb) of 3a and 3b with Ct-DNA obtained from UV-Vis. absorption studies were 8 × 104 and 1 × 105, respectively. Molecular docking of target compounds (3a and 3b) against DNA dodecamer d(CGCGAATTCGCG)2 has been carried out. The test compounds exhibited remarkable antibacterial, antioxidant and DNA binding activities.

 

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Author Biographies

Pattan Sirajuddin Nayab, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India

PhD Scholar

Madhusudana Pulaganti, Department of Biochemistry, Sri Krishnadevraya University, Ananthapuram 515 003, India

Research Associate

Suresh Kumar Chitta, Department of Biochemistry, Sri Krishnadevraya University, Ananthapuram 515 003. India

Professor

Mohammad Oves, Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh 202 002, India

PhD Scholar

Published

2015-08-17

How to Cite

Nayab, P. S., M. Pulaganti, S. K. Chitta, M. Oves, and R. . “Synthesis, Spectroscopic Studies of Novel N-Substituted Phthalimides and Evaluation of Their Antibacterial, Antioxidant, DNA Binding and Molecular Docking Studies”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, Aug. 2015, pp. 703-1, doi:10.3329/bjp.v10i3.23637.

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Section

Research Articles