Medicinal plants with gastroprotective potential
Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.
Abdulla MA, AL-Bayaty FH, Younis LT, Hassan MI. Anti-ulcer activity of Centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats. J Med Plants Res. 2010; 4: 1253-59.
Aghbashlo M, Kianmehr MH, Hassan-Beigi SR. Specific heat and thermal conductivity of berberris fruit (Berberis vulgaris). Am J Agric Biol Sci. 2008; 3: 330-36.
Ahmed SA, Salama MS, Alkiyumi S, Abdulla MA, Hadi AH, Abdelwahab SI, Taha M, Asykin N. Mechanisms of gastroprotective effects of ethanolic leaf extract of Jasminum sambac against HCl/ethanol-induced gastric mucosal injury in rats. J Evid Based Comp Altern Med. 2012; pp 1-15.
Akowuah GA, Sadikun A, Mariam A. Flavonoid identification and hypoglycemic studies of butanol fraction from Gynura procumbens. Pharm Biol. 2002; 40: 405-10.
Akuodor GC, Essien AD, David-Oku E, Chilaka KC, Akpan JL, Ezeokpo B, Ezeonwumelu JOC. Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in albino rats. Asian Pac J Trop Med. 2013; 771-75.
Al-Radahe S, Ahmed KAA, Salama S, Abdulla MA, Amin ZA, Al-Jassabi S, Hashim H. Anti-ulcer activity of Swietenia mahagoni leaf extract in ethanol-induced gastric mucosal damage in rats. J Med Plants Res. 2013; 7: 988-97.
Aniagu SO, Binda LG, Nwinyi FC, Orisadipe A, Amos S, Wambebe C, Gamaniel K. Anti-diarrhoeal and ulcer-protective effects of the aqueous root extract of Guiera senegalensis in rodents. J Ethnopharmacol. 2005; 21; 97: 549-54.
Arawwawala LD, Thabrew MI, Arambewela LS. Gastroprotective activity of Trichosanthes cucumerina in rats. J Ethnopharmacol. 2009; 127: 750-54.
Aslam B, Majeed W, Javed I, Muhammad F, Khaliq T, Khan JA, Ali A, Sindhu Z. Gastroprotective effect of Berberis vulgaris (zereshk) seeds against gastric ulcer induced by aspirin in male adult albino mice. Indo Am J Pharm Res. 2013; 3: 4518-27.
Ayantunde AA. Current opinions in bleeding peptic ulcer disease. J Gastroint Dig Syst. 2014; 4: 1-10.
Biguetti AE, Antonio MA, Kohn MA, Rehder LK, Foglio VG, Possenti MA, Vilela A, Carvalho L. Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata. Phytomed. 2005; 12: 7277.
Bharat BM, Mangala CD, Subas CD, Nagoji KEV. Anti-ulcer activity of aqueous and ethanolic leaf extract of tulasi (Ocimum sanctum) in albino rats. J Pharm Res. 2012; 5: 4060-62.
Calvet X, Garcia N, Lopez T, Gisbert JP, Gene E, Roque M. A meta-analysis of short versus long therapy with a proton pump inhibitor, clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection. Aliment Pharmacol Ther. 2000; 14: 603-09.
Chaudhari M, Mengi S. Evaluation of phytoconstituents of Terminalia arjuna for wound healing activity in rats. Phytother Res. 2006; 20: 799-805.
Chaturvedi A, Kumar MM, Bhawani G, Chaturvedi H, Kumar M, Goel RK. Effect of ethanolic extract of Eugenia jambolana seeds on gastric ulceration and secretion in rats. Indian J Physiol Pharmacol. 2007; 51: 131-40.
Chattopadhyay RR, Bhattacharyya SK. Plant review Terminalia chebula: An update. Pharmacog Rev. 2007; 1: 151-56.
Cheng HC, Chang WL, Yeh YC, Chen WY, Tsai YC, Sheu BS. Seven-day intravenous low-dose omeprazole infusion reduces peptic ulcer rebleeding for patients with comorbidities. Gastrointest Endosc. 2009; 70: 433-39.
Cheng CL, Guo JS, Luk J, Koo MW. The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcer in rats. Life Sci. 2004; 74: 2237-49.
Clayton QA, Jorge MD. Juceni PD, Cristiane FV, Milena BPS, Luciano PQ, Rosane MA. Flavonoids and other bioactive phenolics isolated from Cenostigma macrophyllum (Leguminosae). Quim Nova. 2012; 35: 1-6.
Daihan S. Measurement of selected enzymatic activities in Solanum nigrum treated Biomphalaria arabica snails. J App Sci. 2008; 8: 881-85.
Daniele H, Debora ND, Mariana DM, Livia PH, Eliete NL, Angelo DF, Andreia CCS, Luzia VM. In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas). J Adv Res. 2013; 4: 411-15.
Dilpreet K, Rana AC, Nidhi S, Sunil K. Herbal drugs with anti ulcer activity. J App Pharm Sci. 2012; 3: 160-65.
Elango V, Carolin O, Raghu PS. Antiulcer activity of the leaf ethanolic extract of Mimosa pudica in rats. Hygeia J D Med. 2012; 4: 34-40.
Enaganti S. Peptic ulcer disease: The disease and non drug treatment. Hosp Pharm. 2006; 13: 239-43.
Freitas FFBP, Fernandes HB, Piauilino CA, Pereira SS, Carvalho KIM, Chaves MH, Soares PMG, Miura LMCV, Leite JRSA, Oliveira RCM, Oliveira FA. Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models. J Ethnopharmacol. 2011; 137: 70008.
Galani VJ, Patel BG, Patel NB. Argyreia speciosa (Linn. f.) sweet: A comprehensive review. Pharmacogn Rev. 2010; 4: 17278.
Gill NS, Dhiman K, Sharma P, Bajwa J, Sood S, Sharma PD, Singh B, Bali M. Evaluation of free radical scavenging and antiulcer potential of methanolic extract of Benincasa hispida seeds. Res J Med Plant. 2011; pp 1-9.
Goswami M, Kulshreshtha M, Chandana VR, Yadav S. 2011. Anti-ulcer potential of Lawsonia inermis leaves against gastric ulcers in rats. J App Pharm Sci. 2011; 1: 69-72.
Grover JK, Vats V, Rathi SS. Antihyperglycemic effects of Eugenia jambolana in experimental diabetes and their effects on key metabolic enzymes invovedin carbohydrate metabolism. J Ethnopharmacol. 2000; 73: 461-70.
Grover JK, Adiga G, Vats V, Rathi SS. Extracts of Benincas hispida prevent development of experimental ulcers. J Ethnopharmacol. 2001; 78: 159-64.
Govindarajan R, Vijayakumar M, Singh M, Rao CV, Shirwaikar A, Rawat AS, Pushpangadan P. Antiulcer and antimicrobial activity of Anogeissus latifolia. J Ethnopharmacol. 2006; 106: 57-61.
Gul H, Abbas K, Qadir MI. Gastro-protective effect of ethanolic extract of Mentha longifolia in alcohol- and aspirin-induced gastric ulcer models. Bangladesh J Pharmacol. 2015; 10: 241-45.
Gupta PC, Rao CV. Gastroprotective effect of standardized leaf extract from Careya arborea on experimental gastric ulcers in rats. Pharm Biol. 2014; 52: 1003-08.
Harish KH, Anup P, Shruthi SD. A review on Murraya koenigii: Multipotential medicinal plant. Asian J Pharm Clin Res. 2012; 5: 5-14.
Hemamalini K, Ashok P, Sunny G, Reddy SK, Ganesh G, Santoshini K, Rashmita K, Priyanka P, Jayasri Y, Vishwanath T, Vassireddy U. Gastroprotective activity of Gymnosporia emerginata, Solanum pubescence and Anogessius accuminata leaf extract against ethanol-induced gastric mucosal injury in rats. Int J Pharm Biomed Res. 2011; 2: 38-42.
Hong SS, Kim JH, Shim CK. Advanced formulation and pharmacological activity of hydrogel of titrated extract of C. asiatica. Arch Pharma Res. 2005; 28: 502-08.
Huang JQ, Scidher S, Hunt RH. Role of Helicobacter pylori infection and non-steroidal anti inflammatory drugs in peptic ulcer: A meta-analysis. Lancet 2002; 539: 14-22.
Iskander MN, Song Y, Coupar IM, Iratchariyakul W. Antiinflammatory screening of the medicinal plant Gynura procumbens. Plant Foods Human Nutr. 2002; 57: 233-44.
Jeng HL. Role of proton pump inhibitors in the management of peptic ulcer bleeding. World J Gastrointest Pharmacol Ther. 2010; 1: 51-53.
Jaiswal SK, Rao CV, Sharma B, Mishra P, Das S, Dubey MK. Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats. J Ethnopharmacol. 2011; 137: 341-44.
Kamal K, Kenganora M, Satish K, Rajendran M. Antiulcer activity of ethanol extract of the stem bark of Careya arborea Roxb. Int Curr Pharm J. 2013; 2: 78-82.
Kavitha B, Yasodamma N, Chaithra D. Antiulcer activity of Pterolobium hexapetalum leaf and fruit extracts on pyloric ligated rats. Indo Am J Pharm Res. 2014; 4: 212-19.
Kesari AN, Gupta RK, Watal G. Hypoglycemic effect of Murraya koenigii on normal and alloxan diabetic rabbits. J Ethnopharmacol. 2005; 97: 247-51.
Kenneth T, Soreide JA, Kvaloy JT, Glomsaker T, Soreide K. Epidemiology of perforated peptic ulcer: Age and gender adjusted analysis of incidence and mortality. World J Gastroenterol. 2013; 19: 347-54.
Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 2005; 4: 206-20.
Kou J, Zhu MR, Yan D. Blood-activating and anti-inflamma-tory actions of Polygala fallax. J Zhong Yao Cai. 2003; 26: 26871.
Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection. Gastroenterology 2008; 135: 4160.
Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012; 107: 345-60.
Mahmood AA, Abdalbasit AM, Al-Bayaty F, Ibrahim S. Anti-ulcerogenic activity of Gynura procumbens leaf extract against experimentally-induced gastric lesions in rats. J Med Plants Res. 2010; 4: 685-91.
Manish AR, Sunita MJ. Gastroprotective effect of Benincasa hispida fruit extract. Indian J Pharmacol. 2008; 40: 271-75.
Mazumder PM, Farswan M, Parcha V, Singh V. Hypoglycemic and antioxidant activity of an isolated compound from Ficus arnottiana bark. Pharmacol Online. 2008; 3: 509-19.
Mallika J, Mohan KV, Devi CS. Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res. 2006; 123: 799-806.
Malairajan P, Krishnan GG, Narasimhan S, Jessika K. Evaluation of Anti-ulcer activity of Polyalthia longifolia in experimental animals. Indian J Pharmacol. 2008; 40: 126-28.
Mohsen M, Ghannadi A, Mahzouni P, Shirazi EJ. Comparative study of Berberis vulgaris fruit extract and berberine chloride effects on acetic acid induced colitis in rats. Iran J Pharm Res. 2011; 10: 97-104.
Muralidharan P, Srikanth J. Antiulcer activity of Morinda citrifolia linn fruit extract. J Sci Res. 2009; 1: 345-52.
Naveen J, Jyothi Y, Somashekhar M. Antiulcer activity of Aleo vera gel and its interaction with conventionally used antiulcer drug pantoprazole in rat. Am J Pharm Tech Res. 2013; 3: 290-97.
Neelapu N, Muvvala S, Mrityunjaya B, Lakshmi BVS. Anti-ulcer activity and HPTLC analysis of Mangifera indica L. leaves. Int J Pharm Phytopharm Res. 2012; 1: 146-55.
Nethravathi K, Chandrashekhar MS, Siddique TA, Lakshminarayana G. Evaluation of antiulcer activity of Mangifera indica kernel, vitamins and zinc sulphate on pylorus ligation and ethanol induced ulcer models in rats. Int J Phytopharm. 2015; 6: 86-97.
Niv Y, Battler A, Abuksis G, Gal E, Sapoznikov B, Vilkin A. Endoscopy in asymptomatic minidose aspirin consumers. Dig Dis Sci. 2005; 50: 78-80.
Nizamuddin BS, Suresh C, Danamma B, Dada M, Maajid A. Evaluation of antiulcer activity in the methanol extract of Acanthus ilicifolius leaves in experimental rats. Int J Pharm Ind Res. 2011; 1: 57-62.
Nurhidayah ABR, Pouya H, Shahram G, Salmah I, Saad T, Mahmood AA. Gastroprotective effect of ethanolic extract of Curcuma xanthorrhiza leaf against ethanol-induced gastric mucosal lesions in Sprague-Dawley rats. 2014; 2014: 1-10.
Okonta J, Ogochukwu AM, Michael UC. Antiulcer activity of methanolic extract and fractions of Picralima nitida seeds (Apocynacaea) in rats. Asian Pac J Trop Med. 2011; 4: 13-15.
Patidar DK. Antiulcer activity of aqueous extract of Murraya koenigii in albino rats. Int J Pharm Bio Sci. 2011; 2: 524-29.
Patricia RO, Flavia B, Juliana AS, Raquel CS, Wagner V, Clelia AH, Luiz CD. Hymenaea stigonocarpa Mart. ex Hayne: A Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models. J Ethnopharmacol. 2012; 143: 8190.
Prabhu K, Rajan S. Assessment of antiulcer activity of ethanolic extract of Mangifera indica seed kernel using acid ethanol induced ulcer model. Int J Curr Microbiol App Sci. 2015; 4: 854-60.
Patil MB, Jalalpure SS, Prakash NS. Antiulcer Properties of alcoholic extract of Cynodon dactylon in rats. Trad Med Nutra. 2005; 6: 115-18.
Panda V, Sonkamble M. Anti-ulcer activity of Ipomoea batatas tubers (sweet potato). J Funct Foods Health Dis. 2012; 2: 48-61.
Prakash P, Prasad K, Nitin M, Vijay MK, Sreenivas RK. Evaluation of antiulcer and antisecretory properties of Calotropis procera root extract. Res J Parm Biol Chem Sci. 2011; 2: 35-42.
Perez MA, Del DP, Siles M, Lanas A. Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection. Aliment Pharmacol Ther. 2005; 21: 65-72.
Pushparay P, Tan CH, Tan BKH. Effects of Averrhoea bilimbi leaf extract on blood glucose and lipid in STZ-diabetic rats. J Ethanopharmacol. 2000; 72: 69-76.
Rahim NA, Hassandarvish P, Golbabapour S, Ismail S, Tayyab S, Abdulla M. Gastroprotective effect of ethanolic extract of Curcuma xanthorrhiza leaf against ethanol-induced gastric mucosal lesions in sprague-dawley rats. BioMed Res Int. 2014; 2: 1-10.
Rajeswari K, Pavani D, Aruna E, Ravi KA, Vallabh V, Jaya RRA. Phytochemical and anti ulcer activity of aqueous extract of Morinda citrifolia fruit in rats. Int J Res Pharm Chem. 2015; 5: 150-53.
Raju D, Ilango K, Chitra VI, Ashish K. Evaluation of anti-ulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats. J Pharm Sci Res. 2009; 1: 101-07.
Rang HP, Dale MM, Ritter M, Moore PK. Pharmacology. 5th ed. Edinburgh, Churchill Livingstones, 2003, p 797.
Rakesh P, Kumar NV, Kohli K. Clinical manifestations, causes and management strategies of peptic ulcer disease. Int J Pharm Sci Drug Res. 2010; 2: 99-106.
Rethinam SD, Narayan S, Vani G, Devi CS. Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. Chem Biol Interact. 2007; 167: 71-83.
Rajeshkumar NV, Joy KL, Kuttan G, Ramsewak RS, Nair MG, Kuttan R. Anticarcinogenic activity of Phyllanthus amarus extract. J Ethnopharmacol. 2002; 81: 17-22.
Sachs G, Shin JM, Howden CW. The clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther. 2006; 23: 28.
Sandler RS. The burden of selected digestive diseases in the United States. Gastroenterol. 2002; 122: 150011.
Sander LE, Lorentz A, Sellge G, Coeffier M, Neipp M, Veres T, Frieling T, Meier PN, Manns MP, Bischoff SC. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. J Gut. 2006; 55: 498-504.
Saravanan S, Dhasarathan P, Indira V, Venkatraman R. Gastroprotective and antioxidant activity of Solanum nigrum against aspirin and cold restraint stress induced ulcerated rats. Res J Immunol. 2011; 4: 1-11.
Sutha D, Sabariah I, Surash R, Mun FY. Investigation of antioxidant and hepatoprotective activity of standardized Curcuma xanthorrhiza rhizome in carbon tetrachloride-induced hepatic damaged rats. Sci World J. 2014; 1-8.
Souri E, Amin GH, Sharifabadi AD, Nazifi A, Farsam H. Antioxidant activity of sixty plants from Iran. Iran J Pharm Res. 2004; 3: 55-59.
Shetty BS, Udupa SL, Udupa AL, Somayaji SN. Effect of C. asiatica on normal and dexamethasone-suppressed wound healing in wistar albino rats. Int J Low Extrem Wounds. 2006; 5: 137-43.
Shimizu N, Watanabe T, Arakawa T, Fujiwara Y, Higuchi K, Kuroki T. Pentoxifylline accelerates gastric ulcer healing in rats: Roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing. Digestion. 2000; 6: 157-64.
Srinivas K, Baboo CRV. Antiulcer activity of Ixora pavetta. Int J Curr Pharm Res. 2011; 3: 1-2.
Tamashiro FP, Sikiru OB, Tavares DA, Lima JC, Marson-Ascencio PG, Donizeti AS, Rios SF, Martins DT. Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lytraceae) in experimental animals. J Ethnopharmacol. 2012; 144: 497-505.
Tomosaka H, Chin YW, Salim AA, Keller WJ, Chai H, Kinghorn AD. Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry). J Phytother Res. 2008; 22: 979-81.
Umamaheswari M, Asokkumar K, Rathidevi R, Sivahanmugam AT, Subhadradevi V, Ravi TK. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum. J Ethnopharmacol. 2007; 110: 464-70.
Venkat RN, Kola V, Sowmya U, Jayapal RGA, Anirudh K. Evaluation of anti-ulcer activity of Momordica charantia in rats. Int J Pharm Biol Sci. 2011; 1: 1-16.
Velmishi V, Cekodhima G, Dervishi E, Cullufi P. Peptic ulcer disease in Albanian children: The role of Helicobacter pylori. Global Adv Res J Microbiol. 2014; 3: 127-32.
Vinothapooshan G, Sundar K. Anti-ulcer activity of Mimosa pudica leaves against gastric ulcer in rats. Res J Pharm Biol Chem Sci. 2010; 1: 606-14.
Viana AFSC, Fernandes HB, Silva FV, Oliveira IS, Freitas FFBP, Machado FDF, Costa CLS, Arcanjo DDR, Chaves MH, Oliveira FA, Oliveira RCM. Gastroprotective activity of Cenostigma macrophyllum Tul. var. acuminate Teles Freire leaves on experimental ulcer models. J Ethnopharmacol. 2013; 150: 316-23.
Vidya S, Ramesh A, Alekhya N, Lohitha I. Antiulcer activity of Eugenia jambolana leaves against ethanol-induced gastric ulcer in albino rats. Int J Pharm Res Dev. 2011; 3: 106-12.
Wasman S, Ameen M, Chua LS, Hamdan S. Gastric protection ability of some medicinal malaysian plants against ethanol induction model in Sprague-Dawdle rats. J Teknol. 2012; 57: 199-209.
Wasman SQ, Mahmood AA, Salehhuddin H, Zahra AA, Salmah I. Cytoprotective activities of Polygonum minus aqueous leaf extract on ethanol-induced gastric ulcer in rats. J Med Plants Res. 2010; 4: 2658-65.
Wasman SQ, Mahmood AA, Lee SC, Mohammed AA, Hamdan S. Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats. Indian J Exp Biol. 2011; 49: 767-72.
Wilson I, Langstrom G, Wahlqvist P, Walan A, Wiklund I, Naesdal I. Management of gastroduodenal ulcers and gastrointestinal symptoms associated with NSAID therapy: A summary of four comparative trials with omeprazole, ranitidine, misoprostol and placebo. Curr Ther Res. 2004; 62: 835-50.
Zaunol MK, Hamid A, Yusof S, Muse R. Antioxidative activity and total phenolic compounds of leaf, root and petiole of four accessions of C. asiatica. Urban Food Chem. 2003; 81: 575-81.
Zeeyauddin K, Narsu ML, Abid M, Ibrahim M. Evaluation of antiulcer activity of Boswellia serrata bark extracts using aspirin induced ulcer model in albino rats. J Med Allied Sci. 2011; 1: 14-20.
Zayachkivska OS, Konturek SJ, Drozdowicz D, Konturek PC, Brzozowski T, Ghegotsky MR. Gastroprotective effects of flavonoids in plant extracts. J Physiol Pharmacol. 2005; 56: 21931.
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