Anti-oxidant and hepatoprotective activities of total flavonoids of Indocalamus latifolius

  • Juan Tan The Department of Life Science, Huaihua University, Huaihua 418008
  • Li Shenghua The Department of Life Science, Huaihua University, Huaihua 418008 http://orcid.org/0000-0002-0042-1855
  • Junying Zeng The Department of Life Science, Huaihua University, Huaihua 418008
  • Xianjin Wu The Department of Life Science, Huaihua University, Huaihua 418008
Keywords: Anti-oxidant, Flavonoid, Hepatoprotective, Indocalamus latifolius

Abstract

The total flavonoids of Indocalamus latifolius were evaluated in term of their anti-oxidant and hepatoprotective activities. The results showed that in vitrohepatoprotective and anti-oxidant activities of total flavonoids at doses of 200 and 400 mg/kg and 100 mg/kg, respectively, were comparable to those of the known hepatoprotective drug silymarin at 100 mg/kg. These data were supplemented with histopathological studies of rat liver sections. Seven of the main flavonoid compounds purified by column chromatography using silica gel, sephadex LH-20 and develosil ODS, and determined to be vitexin, orientin, isovitexin, homoorientin, tricin, tricin-7-O-β-D-glucopyranoside and quercetin-3-O-glucopyranoside.

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References

Afolayan AJ, Aboyade OM, Sofidiya MO. Total phenolics content and free scavenging activity of Malva parviflora. J Biol Sci, 2008; 8: 945-49.

Apak A, Güçlü K, Özyürek M, Celik SE. Mechanism of antioxidant capacity assays and the CUPRAC (cupric ion reducing antioxidant capacity) assay. Microchimica Acta. 2008; 160: 413-19.

Avallone R, Zanoli P, Pula G, Matthias K, Schreier MB. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochemical Pharmacol. 2000; 59: 1387-94.

Awaad AS, Maitland DJ, Soliman GA. Hepatoprotective activity of Schouwia thebica Webb. Bioorg Med Chem Lett. 2006; 16: 4624-28.

Basu S. Carbon tetrachloride-induced lipid peroxidation: Eicosanoid formation and their regulation by antioxidant nutrients. Toxicology 2003; 189: 113-27.

Chen CY, Ding YQ, Elmahadi EA, Zhou JG, Xu HB. Study on the isolation, purification and structural property of polysacchrides from Ruoye (Indocalamus tesselatus). Prog Biochem Biophys. 1999; 25: 51-55.

Flora. Republicae Popularis Sinicae [M]. Beijing, Science Press, 1996; 9: 689-90.

Huang B, Ban X, He J, Tong J, Tian J, Wang YW. Hepato-protective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves. Food Chem. 2010; 120: 873-78.

Jain A, Soni M, Deb L, Jain A, Rout SP. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J Ethnopharmacol. 2008; 115: 61-66.

Kikuzaki H, Nakatani N. Antioxidant effects of some ginger constituents. J Food Sci. 1993; 58: 1407-10.

Li YF, Wen DZ, Zeng D. Extraction and determ ination of essential oils in Indocalamus latifolius leaves and Indocalamus tessellatus leaves. Chinese J Chromatogr. 2007; 25: 53-57.

Li ZZ. Study on the extraction optimal technology of flavoniods from common lophatherun herb and anti-oxidative activity. Food Res Dev. 2008; 29: 42-45.

Liu Q, Yao HY. Antioxidant activities of barley seeds extracts. Food Chem. 2007; 102: 732-37.

Luo JY, Chen XY. Study on extracting tea polyphenols from of Indocalamus. J Chem Industry Forest Prod. 2003; 37: 15-19.

Meir S, Kanner J, Akiri B. Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves. J Agric Food Chem. 1995; 43: 1813-19.

Ordonez AL, Gomez JD, Vattuone MA. Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem. 2006; 97: 452-58.

Osawa T, Namaki M. A novel type antioxidant isolated from leaf wax of Eucalyptus leaves. Agric Biol Chem. 1981; 45: 735-39.

Oyaizu M. Studies on products of browning reactions: Antioxidative activities of products of browning reaction prepared from glucosamine. Japanese J Nutr. 1986; 44: 307-15.

Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999; 26: 1231-37.

Sanchez-Moreno C. Review: Methods used to evaluate the free radical scavenging activity in foods and biological systems. Food Sci Technol Int. 2002; 8: 121-37.

Shenoy KA, Somayaji SN, Bairy KL. Hepatoprotective effects of Ginkgo biloba against carbon tetrachloride induced hepatic injury in rats. Indian J Pharmacol. 2001; 33: 260-66.

Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J Agric Food Chem. 1992; 40: 945-48.

Shon MY, Kim TH, Sung NJ. Antioxidants and free radical scavenging activity of Phellinus baumii (Phellinus of Hymenochaetaceae) extracts. Food Chem. 2003; 82: 593-97.

Xiang TY, Zhang C, Xie DP. The separation and purification of the bioactive substances of Indocalamus leaves. J Hubei Institute Nationalities. 2002; 22: 73-74.

Xiang Z, Ning ZX. Scavenging and antioxidant properties of compound derived from chlorogenic acid in South-China honeysuckle. LWT-Food Sci Technol. 2008; 41: 1189-203.

Xu XY, Xie HH, Hao J, Jiang YM, Wei XY. Flavonoid glycosides from the seeds of Litchi chinensis. J Agric Food Chem. 2011; 59: 1205-09.

Wang DY, Zhao Y, Jiao YD, Yu LH, Yang F,Yang XB. Antioxidative and hepatoprotective effects of the polysaccharides from Zizyphus jujubae cv. Shaanbeitanzao. Carbohydrate Polymers. 2012; 88: 1453-59.

Published
2015-09-26
How to Cite
Tan, J., L. Shenghua, J. Zeng, and X. Wu. “Anti-Oxidant and Hepatoprotective Activities of Total Flavonoids of Indocalamus Latifolius”. Bangladesh Journal of Pharmacology, Vol. 10, no. 4, Sept. 2015, pp. 779-8, doi:10.3329/bjp.v10i4.23496.
Section
Research Articles