Pharmacologically mechanistic basis for the traditional uses of Rumex acetosa in gut motility disorders and emesis

Authors

  • Musaddique Hussain Faculty of Pharmacy, Bahauddin Zakariya University, MultanSchool of Pharmacy, The University ofFaisalabad, Faisalabad, Pakistan http://orcid.org/0000-0001-8766-6339
  • Shahid Masood Raza School of Pharmacy, The University ofFaisalabad, Faisalabad, Pakistan
  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

DOI:

https://doi.org/10.3329/bjp.v10i3.23406

Keywords:

Antiemetic, Ca2 antagonist, Cholinomimetic, Spasmogenic, Spasmolytic

Abstract

In vitro and in vivo studies were undertaken to evaluate the pharmacologically mechanistic background to validate the traditional uses of Rumex acetosa in the treatment of emesis and gastrointestinal motility disorders such as constipation and diarrhea. In rabbit jejunum preparation, methanolic extract of R. acetosa (0.01-1.0 mg/mL) caused a transient spasmogenic effect, followed by the spasmolytic effect (3-10 mg/mL). In presence of atropine, spasmogenic effect was blocked while spasmolytic effect was emerged, suggesting that spasmogenic effect was mediated through activation of muscarinic receptors. Extract inhibited the K+ (80 mM)-induced contraction, suggesting Ca2+-cha-nnel blockade, which was further confirmed when pretreatment of tissue with extract shifted the Ca2+ concentration-response curves to the right, similarly as verapamil. R. acetosa also exhibited the significant antiemetic activity (p<0.05) against different emetogenic stimuli, when compared with chlorpromazine. This study confirms the presence of gut modulator (spasmogenic and spasmolytic) and antiemetic activates, validating its traditional uses.

 

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Author Biographies

Musaddique Hussain, Faculty of Pharmacy, Bahauddin Zakariya University, MultanSchool of Pharmacy, The University ofFaisalabad, Faisalabad, Pakistan

Lecturer

Khalid Hussain Janbaz, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

Published

2015-07-01

How to Cite

Hussain, M., S. M. Raza, and K. H. Janbaz. “Pharmacologically Mechanistic Basis for the Traditional Uses of Rumex Acetosa in Gut Motility Disorders and Emesis”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 548-54, doi:10.3329/bjp.v10i3.23406.

Issue

Section

Research Articles