Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats





Bezafibrate, Fenofibrate, 2-Oxoglutarate dehydrogenase


Multienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase  belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up-regulate liver BCKDH. The present study has been undertaken to determine the effect of low doses of bezafibrate and fenofibrate on liver 2-OGDH. Fibrates were administrated to rats fed low-protein diet at 5, 10 or 20 mg/kg. In rats treated with increasing doses of bezafibrate 2-OGDH activity increased by 7, 35 and 42%, while in rats administered with fenofibrate by 8, 18, and 56% (p<0.05 for bezafibrate 10 and 20, and fenofibrate 20 mg/kg). Changes in 2-OGDH activity did not correspond with changes in mRNA levels of the complex enzymes. Moreover, mRNA levels of PPAR? remained unaltered. It is conceivable that stimulation of 2-OGDH activity by low doses of fibrates is the result of post-transcriptional events and may have a significant effect on liver metabolism.



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How to Cite

Knapik-Czajka, M. E. “Effect of Low Doses of Bezafibrate and Fenofibrate on Liver 2-Oxo-Glutarate Dehydrogenase Complex in Low-Protein Diet Fed Rats”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 505-12, doi:10.3329/bjp.v10i3.23101.



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