MHC class I-presented tumor antigen appraisable for T-cell responses against ovarian cancer

Authors

  • Jing Yao Wang Departmentof Gynecology, Second Hospital of Tianjin Medical University; Department of Gynaecology and Obstetrics, Tangshan Maternal and Children Health Hospital
  • Nan Zhang Department of Orthopedics, Tangshan Kailuan General Hospital, Tangshan 063 000
  • Xiaojie Yang Department of Gynecology and Obstetrics, Tangshan Maternal and Children Health Hospital, Tangshan 063 000
  • Danli Gao Department of Gynecology and Obstetrics, Tangshan Maternal and Children Health Hospital, Tangshan 063000
  • Lirong Yin Department of Gynecology, Second Hospital of Tianjin Medical University, Tianjin 300211
  • Shuying Ji Department of Gynecology and Obstetrics, Tangshan Maternal and Children Health Hospital, Tangshan 063 000

DOI:

https://doi.org/10.3329/bjp.v10i3.23076

Keywords:

MHC Class I, Ovarian cancer, T-Cell response, Tumor antigen

Abstract

The purpose of this study is to assess whether MHC class I-presented tumor antigen is appraisable for T-cell responses against ovarian cancer. In ovarian cancer cell, human leukocyte antigen A2 (HLA-A2) associated with peptides was used to promote the activation of naive T cells so as to activate antigen-specific T cells. 7 or 4 patients were observed grade 1 or 2 injection site reactions, respectively. 5, 2 or 1 patients were observed grade 1, 2 or 3 pain reactions, respectively. 4 or 1 patients were observed grade 1 or 2 induration reactions. Total number mean value of patients experiencing response to the particular peptide was 7.73, and total number mean value of peptides to which the patients responded was 7.45. MHC class I-presented tumor antigen is appraisable for T-cell responses against ovarian cancer in China.

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Additional Files

Published

2015-07-01

How to Cite

Wang, J. Y., N. Zhang, X. Yang, D. Gao, L. Yin, and S. Ji. “MHC Class I-Presented Tumor Antigen Appraisable for T-Cell Responses Against Ovarian Cancer”. Bangladesh Journal of Pharmacology, vol. 10, no. 3, July 2015, pp. 524-8, doi:10.3329/bjp.v10i3.23076.

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Section

Research Articles