In vitro inhibitory potential of methanolic extract of Celosia argentea var. cristata on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

  • Fatima Saqib Faculty of Pharmacy, Bahaudin Zakariya University, Multan
  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahaudin Zakariya University, Multan
  • Maryam Khan Sherwani Faculty of Pharmacy, Bahaudin Zakariya University, Multan
Keywords: Acetylcholinesterase, Butyrylcholinesterase, Celosia argentea var. cristata, Neurodegenarative disorders, Tyrosinase

Abstract

In the current study, methanol extract of Celosia argentea var. cristata was tested for its inhibitory potential against tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes at the concentration of 0.5 mM by ELISA microtiter plate assays. A significant tyrosinase inhibitory activity (63.6%), acetylcholinesterase inhibitory activity (80.3%) and butyrylcholinesterse inhibitory activity (68.24%) was shown by crude methanolic extract of C. argentea var. cristata with respective IC50 values of 268.5 ± 0.2 µg/mL, 73.6 ± 0.1 µg/mL and 132.8 ± 0.9 µg/mL. The result of this study reveals the use of C. argentea var. cristata in skin hyperpigmentation, Parkinsons disease and neurodegenerative disorders like Alzheimers disease and dementia.

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Published
2015-05-24
How to Cite
Saqib, F., K. Janbaz, and M. Sherwani. “In Vitro Inhibitory Potential of Methanolic Extract of Celosia Argentea Var. Cristata on Tyrosinase, Acetylcholinesterase and Butyrylcholinesterase Enzymes”. Bangladesh Journal of Pharmacology, Vol. 10, no. 2, May 2015, pp. 449-54, doi:10.3329/bjp.v10i2.22880.
Section
Research Articles