Antidiarrheal and antispasmodic activities of Adiantum capillus-veneris are predominantly mediated through ATP-dependent K+ channels activation

  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60 800, Pakistan
  • Waseem Hassan Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74 800
  • Malik Hassan Mehmood Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74 800
  • Anwar Hassan Gilani Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74 800
Keywords: Adiantum capillus-veneris, Antidiarrheal, Antispasmodic, ATP-dependent K channel activation

Abstract

The study was tempted to explore the scientific basis for the medicinal use of Adiantum capillus-veneris L. in diarrhea using the in vivo and in vitro assays. The crude extract of dried leaves of A. capillus-veneris exhibited antidiarrheal effect against castor oil-induced diarrhea in mice at 300 and 500 mg/kg, similar to the effect loperamide. It was also found safe up to administered dose of 7 g/kg in mice. In isolated rabbit jejunum, extract of A. capillus-veneris showed a concentration-dependent relaxation of spontaneous and low K+ (25 mM)-induced contractions and had weak inhibitory effect on high K+ (80 mM), similar to the activity pattern of cromakalim, an ATP-dependent K+ channel opener. Interestingly, its inhibitory effect on spontaneous contractions was potentiated in the presence of atropine. These data demonstrates that A. capillus-veneris possesses antidiarrheal and antispasmodic properties mediated possibly through ATP-dependent K+ channels activation, thus providing scientific basis to its folk use in abdominal colic and diarrhea.

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Author Biography

Anwar Hassan Gilani, Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74 800

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Published
2015-03-13
How to Cite
Janbaz, K., W. Hassan, M. Mehmood, and A. Gilani. “Antidiarrheal and Antispasmodic Activities of Adiantum Capillus-Veneris Are Predominantly Mediated through ATP-Dependent K+ Channels Activation”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Mar. 2015, pp. 222-9, doi:10.3329/bjp.v10i1.21869.
Section
Research Articles