Gastro-protective effect of ethanolic extract of Mentha longifolia in alcohol- and aspirin-induced gastric ulcer models

  • Humaira Gul Faculty of Pharmaceutical Sciences, GC University, Faisalabad
  • Khizar Abbas Faculty of Pharmaceutical Sciences, GC University, Faisalabad
  • Muhammad Imran Qadir Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan
Keywords: Anti-ulcer, Mentha longifolia


The objective of the study was to evaluate anti-ulcer potential of Mentha longifolia. The rats (four groups) were given orally the vehicle (normal saline, 2 mL/kg) as control group, ethanol extracts of the plant at dose of 100 mg/kg and 200 mg/kg of body weight and ranitidine (20 mg/kg) as standard drug (positive control). Ulcer was induced by oral administration of alcohol (80%) and aspirin (200 mg/kg). The gastric tissues were examined to determine ulcer index and percentage protection. Histopathological evaluation was also performed to support the results. Ethanol extract of M. longifolia showed reduction in ulcer index (p<0.05). Treatment with ethanolic extract of M. longifolia at dose of 100 mg/kg and 200 mg/kg of body weight gave ulcer protection (30.5 ± 4.5%) and (47.1 ± 5.9%) respectively. In conclusion, ethanolic extract of M. longifolia has anti-ulcer activity.


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Abdulla MA, Alrashdi AS, Salama SM, Alkiyumi SS, Hadi AHA, Abdelwahab SI, Taha MM, Hussaini J, Asykin N. Mechanisms of gastroprotective effects of ethanolic leaf extract of Jasminum sambac against HCl/ethanol-induced gastric mucosal injury in rats. Evidence-Based Complem Alter Med. 2012; 1-15.

Ali M, Qadir MI, Saleem M, Janbaz KH, Gul H, Hussain L, Ahmed B. Hepatoprotective potential of Convolvulus arvensis against paracetamol-induced hepatotoxicity. Bangladesh J Pharmacol. 2013; 8: 300-04.

Amin N, Qadir MI, Khan TJ, Abbas G, Ahmad B, Janbaz KH, Ali M. Antibacterial activity of vacuum liquid chromatography (VLC) isolated fractions of chloroform extracts of seeds of Achyranthes aspera. J Chem Soc Pak. 2012; 34: 589-92.

Dhasan PB, Jagadeesan M. Gastro protective activity of Momordica cymbalaria fruits against experimentally induced gastric ulcer in rats. Inter J Phytomed. 2010; 2: 385-91.

Ehsan O, Qadir MI, Malik SA, Abbassi WS, Ahmad B. Efficacy of nanogold-insulin as a hypoglycemic agent. J Chem Soc Pak. 2012; 34: 365-70.

Gupta J, Kumar D, Gupta A. Evaluation of gastric anti-ulcer activity of methanolic extract of Cayratia trifolia in experimental animals. Asian Pacific J Trop Dis. 2012; 2: 99-102.

Haq F, Ahmed H, Alam M. Traditional uses of medicinal plants of Nandiar Khuwarr catchment (District Battagram), Pakistan. J Med Plants Res., 2011; 5: 39-48.

Hazrat A, Nisar M, Shah J, Ahmad S. Ethnobotanical study of some elite plants belonging to Dir, Kohistan Valley, Khyber Pukhtunkhwa, Pakistan. Pak J Bot. 2011; 43: 787-95.

Hussain A, Khalid SH, Qadir MI, Massud A, Ali M, Khan IU, Saleem M, Iqbal MS, Asghar S, Gul H. Water uptake and drug release behaviour of methyl methacrylate-co-itaconic acid [P(MMA/IA)] hydrogels cross-linked with methylene bis-acrylamide. J Drug Deliv Sci Tech. 2011; 21: 249-55.

Janbaz KH, Nisar U, Ashraf M, Qadir MI. Spasmolytic, bronchodilator and antioxidant activities of Erythrina superosa Roxb. Acta Pol Pharm. 2012; 69: 1111-17.

Javed F, Qadir MI, Janbaz KH, Ali M. Novel drugs from marine microorganisms. Cr Rev Microbiol. 2011; 37: 245-49.

Khalid SH, Qadir MI, Massud A, Ali M, Rasool MH. Effect of degree of cross-linking on swelling and drug release behaviour of poly (methyl methacrylate-co-itaconic acid) [P(MMA/IA)] hydrogels for site specific drug delivery. J Drug Deliv Sci Tech. 2009; 19: 413-18.

Khatib N, Angel G, Nayna H, Kumar JR. Gastroprotective activity of the aqueous extract from the roots of daucus carota L in rats. Inter J Res Ayur Pharm. 2010; 1: 112-19.

Kumar M, Paul Y, Anand VK. An ethnobotanical study of medicinal plants used by the locals in Kishtwar, Jammu and Kashmir, India. Ethnobot Leaf, 2009; 13: 1240-56.

Mallhi TH, Qadir MI, Khan YH, Ali M. Hepatoprotective activity of aqueous methanolic extract of Morus nigra against paracetamol-induced hepatotoxicity in mice. Bangladesh J Pharmacol. 2014; 9: 60-66.

Masood MI, Qadir MI, Shirazi JH, Khan IU. Beneficial effects of lactic acid bacteria on human beings. Cr Rev Microbiol. 2011; 37: 9198.

Naz S, Qadir MI, Ali M, Janbaz KH. Nanotechnology for imaging and drug delivery in cancer. J Chem Soc Pak. 2011; 34: 107-11.

Nickavar B, Alinaghi A, Kamainejad M. Evaluation of the antioxidant properties of five Mentha species. Iran J Pharma Res. 2008; 7: 203-09.

Qadir MI. Medicinal and cosmetological importance of Aloe vera. Int J Nat Ther. 2009; 2: 21-26.

Qadir MI. Medicinal values of ginger. Int J Nat Ther. 2009; 3: 19-22.

Qadir MI. Qadirvirtide. Pak J Pharm Sci. 2011; 24: 593-95.

Razavi SM, ZarriniG, Molavi G. The evaluation of some bilogical activity of Mentha longifolia (L.) huds growing wild in iran. Pharmacologia 2012; 3, 535-38.

Saleem M, Ahmed B, Qadir MI, Mahrukh, Rafiq M, Ahmad M, Ahmad B. Hepatoprotective effect of Chenopodium murale in mice. Bangladesh J Pharmacol. 2014; 9: 124-28.

Vinothapooshan G, Sundar K. Anti-ulcer activity of Mimosa pudica leaves against gastric ulcer in rats. Res J Pharma Bio Chem Sci. 2010; 1: 606-14.

How to Cite
Gul, H., K. Abbas, and M. I. Qadir. “Gastro-Protective Effect of Ethanolic Extract of Mentha Longifolia in Alcohol- and Aspirin-Induced Gastric Ulcer Models”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Mar. 2015, pp. 241-5, doi:10.3329/bjp.v10i1.21689.
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