Targeting breast cancer using retinoic acid trifloromethyl chalcone: A promising therapeutic strategy in the treatment of breast cancer

  • Hao Ding Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
  • Ben-Zhong Wang Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
  • Hua-Qing Zhu Department of Biochemistry, Anhui Medical University, Hefei 230022
  • Liu-Yi Dong Department of Pharmacology, Anhui Medical University, Hefei 230022
  • Yu-Fang Gu Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
  • Yu Zhao Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022
Keywords: Breast cancer, Retinoic acid trifloromethyl chalcone, Therapeutic strategy

Abstract

The study was devised to investigate the effect of retinoic acid trifloromethyl chalcone (RAFC) on mammary carcinogenesis in female rats. The data revealed a significant decrease in number of rats with mammary tumor, number of tumors per rat and tumor volume by 54, 72 and 75% respectively in RAFC group compared to control group. The ibuprofen treated rats also showed a significant decrease in number of rats with tumor, number of tumors per rat and tumor volumes by 43%, 55%, and 59%, respectively. Treatment of rats with RAFC also increased the latency period of tumor induction significantly. Median detection period (50% of tumors) was 92, 83 and 56 days respectively in the rats from RAFC, ibuprofen and control groups respectively after DMBA induction. These results demonstrate that RAFC possesses strong chemopreventive activity against mammary carcinogenesis. 

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Published
2015-03-11
How to Cite
Ding, H., B.-Z. Wang, H.-Q. Zhu, L.-Y. Dong, Y.-F. Gu, and Y. Zhao. “Targeting Breast Cancer Using Retinoic Acid Trifloromethyl Chalcone: A Promising Therapeutic Strategy in the Treatment of Breast Cancer”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Mar. 2015, pp. 209-13, doi:10.3329/bjp.v10i1.21599.
Section
Research Articles