In vitro acetylcholinesterase and butyrylcholinesterase inhibitory potentials of essential oil of Artemisia macrocephala

  • Mohammad Shoaib Department of Pharmacy, University of Malakand, Chakdara Dir Lower, KPK
  • Ismail Shah Department of Pharmacy, University of Malakand, Chakdara Dir Lower, KPK
  • Niaz Ali Institute of Basic Medical Sciences, Khyber Medical University Peshawar, KPK
  • Syed Wadood Ali Shah Department of Pharmacy, University of Malakand, Chakdara Dir Lower, KPK
Keywords: Acetylcholinesterase, A. macrocephala, butrylcholinesterase, Essential oil

Abstract

In this study we screened the essential oil of Artemisia macrocephala for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potentials. Ellman's assay method was used to investigate the enzyme inhibitory potential of the essential oil. The oil sample showed 87.7 ± 1.2, 77.9 ± 0.6, 74.5 ± 1.9 and 62.5 ± 0.3 percent AChE inhibition at 1000, 500, 250 and 125 ?g/mL concentrations respectively with IC50 value of 40 ?g/mL. Similarly it showed 81.8 ± 0.6, 75.6 ± 1.2, 70.0 ± 0.6 and 64.2 ± 1.4 percent BChE inhibition in 1000, 500, 250 and 125 ?g/mL concentrations respectively with IC50 value of 30 ?g/mL. The results of this study confirm the beneficial applications of the oil sample in the treatment of various neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, ataxia and all other forms of dementia.

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Author Biography

Ismail Shah, Department of Pharmacy, University of Malakand, Chakdara Dir Lower, KPK
PhD Scholar

References

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Published
2015-01-27
How to Cite
Shoaib, M., I. Shah, N. Ali, and S. Shah. “In Vitro Acetylcholinesterase and Butyrylcholinesterase Inhibitory Potentials of Essential Oil of Artemisia Macrocephala”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Jan. 2015, pp. 87-91, doi:10.3329/bjp.v10i1.21171.
Section
Research Articles