Retinoic acid ortho-hydroxy aniline amide promotes neurotrophin mediated cell growth and proliferation in nerve cells

  • Zhi-Gang Wang Department of Neurosurgery, Qilu Hospital of Qingdao Branch?Shandong University, Qingdao 266035
  • Jin-Peng Wang Department of Neurosurgery, Brain Hospital of Weifang People?s Hospital, Weifang 261041
  • Fang Wang Department of Neurosurgery, Qilu Hospital of Qingdao Branch?Shandong University, Qingdao 266035
  • Yi-Hua Wang Department of Neurosurgery, Brain Hospital of Weifang People?s Hospital, Weifang 261041
  • Pei-Cheng Cao Department of Neurosurgery, Qilu Hospital of Qingdao Branch?Shandong University, Qingdao 266035
Keywords: Neuronal differentiation, Proliferation, Stem cell, Retinoic acid amide

Abstract

In the present study, effect of retinoic acid ortho-hydroxy aniline amide (RAA), an analog of retinoic acid (RA) was investigated on neurotrophin mediated cell growth and proliferation in hippocampus-derived stem cell clones. The results revealed that retinoic acid ortho-hydroxy aniline amide enhanced neuronal differentiation, increased NeuroD expression and p21 compared to proliferating cells stimulated by FGF-2. Retinoic acid ortho-hydroxy aniline amide treatment prevented decrease in RNA for trkC, enhanced expression of trkB RNA and p75NGFR. Retinoic acid ortho-hydroxy aniline amide treatment for 5 days increased the baseline expression of c-fos mRNA following stimulation with NGF, BDNF, and NT-3. Treatment of cultures with retinoic acid ortho-hydroxy aniline amide for 5 days followed by 5 days in serum alone increased Map2ab-positive cells compared to that of control. Therefore, retinoic acid ortho-hydroxy aniline amide is an effective agent for inducing neuronal differentiation and proliferation and is even more potent than the parent retinoic acid.

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Published
2015-01-11
How to Cite
Wang, Z.-G., J.-P. Wang, F. Wang, Y.-H. Wang, and P.-C. Cao. “Retinoic Acid Ortho-Hydroxy Aniline Amide Promotes Neurotrophin Mediated Cell Growth and Proliferation in Nerve Cells”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Jan. 2015, pp. 40-46, doi:10.3329/bjp.v10i1.20921.
Section
Research Articles