Pharmacological basis for the medicinal use of Rhus coriaria in hyperactive gut disorders

  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahauddin Zakariya University, Multan-60800, Pakistan
  • Arham Shabbir 1Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan 2Faculty of Pharmacy, Bahauddin Zakariya University, Multan-60800, Pakistan 3Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan
  • Malik Hassan Mehmood 1Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan
  • Anwarul Hassan Gilani Aga Khan University
Keywords: Antidiarrheal, Antisecretory, Antispasmodic, Ca-antagonist, Rhus coriaria

Abstract

This study was aimed at providing the pharmacological basis for the medicinal use of Rhus coriaria in diarrhea. In mice, the crude of R. coriaria demonstrated antisecretory and antidiarrheal effects against castor oil-induced fluid accumulation and diarrhea at at 100 and 300 mg/kg, respectively, and was found safe up to tested dose of 5 g/kg. In isolated rabbit jejunum, R. coriaria exhibited concentration-dependent (0.01-3.0 mg/mL) relaxation of spontaneous and high K+ (80 mM)-induced contractions, similar to verapamil. The Ca++ antagonist activity was confirmed when pretreatment of R. coriaria shifted Ca++ concentration-response curves to the right with suppression of maximal response, similar to verapamil. R. coriaria also suppressed the high K+-evoked transient contractile peaks similar to the effect of cyclopiazonic acid and verapamil. This study indicates that R. coriaria possesses antisecretory, antidiarrheal and antispasmodic properties mediated possibly through Ca++ antagonist pathway, thus providing evidence to its medicinal use in diarrhea and abdominal spasm.

DOI: http://dx.doi.org/10.3329/bjp.v9i4.20879

 

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Author Biographies

Khalid Hussain Janbaz, Faculty of Pharmacy, Bahauddin Zakariya University, Multan-60800, Pakistan
Faculty of Pharmacy, Professor
Arham Shabbir, 1Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan 2Faculty of Pharmacy, Bahauddin Zakariya University, Multan-60800, Pakistan 3Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan
Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Lecturer
Malik Hassan Mehmood, 1Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan
Department of Biological and Biomedical Sciences, Assistant Professor
Anwarul Hassan Gilani, Aga Khan University
Biological and Biomedical Sciences, Professor

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Published
2014-12-01
How to Cite
Janbaz, K., A. Shabbir, M. Mehmood, and A. Gilani. “Pharmacological Basis for the Medicinal Use of Rhus Coriaria in Hyperactive Gut Disorders”. Bangladesh Journal of Pharmacology, Vol. 9, no. 4, Dec. 2014, pp. 636-44, doi:10.3329/bjp.v9i4.20879.
Section
Research Articles