Evaluation of hepatoprotective effect of chloroform and methanol extracts of Opuntia monacantha in paracetamol-induced hepatotoxicity in rabbits

Authors

  • Mohammad Saleem College of Pharmacy, GC university Faisalabad
  • Iram Irshad College of Pharmacy, GC University, Faisalabad, Pakistan
  • Muhammad Kashif Baig Independent Medical College, Faisalabad
  • Faiza Naseer College of Pharmacy, GC university Faisalabad

DOI:

https://doi.org/10.3329/bjp.v10i1.20825

Keywords:

Hepatoprotective, Opuntia monacantha, Paracetamol, Silymarin

Abstract

The chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showed significant (p<0.001) hepatoprotective activity by reducing the magnitude of liver markers including alanine aminotransferase, aspartate aminotransferase, alkaline phasphatase and total bilirubin levels. The results were supported by histopathological studies of liver tissue. Chemical analysis of O. monacantha indicated the presence of alkaloids, tannins, saponins, flavonoids and  polysaccharides and its hepato-protective potential may be due to the presence of flavonoids. Its is concluded that 600 mg/kg is the potent dose of both extracts of O. monacantha as hepatoprotective plant.

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Published

2015-01-03

How to Cite

Saleem, M., I. Irshad, M. K. Baig, and F. Naseer. “Evaluation of Hepatoprotective Effect of Chloroform and Methanol Extracts of Opuntia Monacantha in Paracetamol-Induced Hepatotoxicity in Rabbits”. Bangladesh Journal of Pharmacology, vol. 10, no. 1, Jan. 2015, pp. 16-20, doi:10.3329/bjp.v10i1.20825.

Issue

Vol. 10 No. 1 (2015)

Section

Research Articles

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