Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: In vitro and in vivo antineoplastic activity

  • Satyajit Dutta Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar Pradesh
  • G. Raghava Ravali Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy & Allied Health Sciences, Durgapur 713206, West Bengal
  • Supratim Ray Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam
  • K. Nagarajan Department of Pharmaceutical Chemistry, KIET School of Pharmacy, Muradnagar, Ghaziabad 201206, Uttar Pradesh
Keywords: Glutamic acid (2-amino pentanedioic acid), Anticancer, MTT assay, Ehrlich ascites carcinoma.

Abstract

In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The in vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ovarian cancer (OVACAR-3), human colon adenocarcinoma (HT-29) and Human kidney carcinoma (A-498). The in vivo activity was performed in female swiss albino mice against Ehrlich ascites carcinoma (EAC). Among the synthesized compounds, ureide, p-bromoanilide, p-nitoanilide, o-bromoanilide and p-methylanilide derivatives of 2-(4-methyl benzene sulphonyl)-pentanedioic acid amides showed encouraging activity in both the in vitro and in vivo compared to other compounds. It was noticed that final derivative compounds show a better activity than the parent compound and it may be due to the substituents present in those compounds.

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Author Biographies

Supratim Ray, Department of Pharmaceutical Sciences, Assam University, Silchar 788011, Assam
Associate Professor
K. Nagarajan, Department of Pharmaceutical Chemistry, KIET School of Pharmacy, Muradnagar, Ghaziabad 201206, Uttar Pradesh
Professor

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Published
2015-01-01
How to Cite
Dutta, S., G. Ravali, S. Ray, and K. Nagarajan. “Synthesis, Structural Characterization and Biological Activity of 2-(4-Methylbenzenesulphonamido)pentanedioic Acid Amide Derivatives: In Vitro and in Vivo Antineoplastic Activity”. Bangladesh Journal of Pharmacology, Vol. 10, no. 1, Jan. 2015, pp. 7-15, doi:10.3329/bjp.v10i1.20748.
Section
Research Articles