Hepatoprotective activity of fruit extract of Garcinia pedunculata

Authors

  • Ravi Mundugaru Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi 574118
  • Madhan Chakkravarthy Department of Research and Development, Biomedical Research Unit and Laboratory Animal Center, Saveetha University Thandalam, Chennai 602105
  • Ravishankar Basavaiah Department of Pharmacology and Toxicology, SDM Center for Research in Ayurveda and Allied Sciences, Udupi 574 118

DOI:

https://doi.org/10.3329/bjp.v9i4.19910

Keywords:

Garcinia pedunculata, Hepatoprotective, Paracetamol, Silymarin

Abstract

The objective of this study was to explore the hepatoprotective activity of fruits of Garcinia pedunculata in paracetamol-induced liver toxicity in rats. Paracetamol-induced hepatotoxicity was evaluated by an increase in serum transaminases and alkaline phosphatase activity. Histopathological observation showed extensive disturbance in the liver cytoarchitecture in comparison to normal control liver sections. Pre-treatment with aqueous extract of fruits of G. pedunculata prevented the paracetamol-induced increase in serum transaminases, alkaline phosphatase and histopathological changes. Based on the above observation it can be concluded that G. pedunculata pretreatment exhibited significant hepatoprotective activity against paracetamol-induced hepatotoxicity.

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Author Biographies

Madhan Chakkravarthy, Department of Research and Development, Biomedical Research Unit and Laboratory Animal Center, Saveetha University Thandalam, Chennai 602105

Assistant Professor

Ravishankar Basavaiah, Department of Pharmacology and Toxicology, SDM Center for Research in Ayurveda and Allied Sciences, Udupi 574 118

Professor & Head

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Additional Files

Published

2014-10-01

How to Cite

Mundugaru, R., M. Chakkravarthy, and R. Basavaiah. “Hepatoprotective Activity of Fruit Extract of Garcinia Pedunculata”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 483-7, doi:10.3329/bjp.v9i4.19910.

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Section

Research Articles