Hypoglycemic activity of aqueous leaf extract of Limonia elephantum in alloxan-induced diabetic rats

  • K. Kamalakannan Department of Biotechnology, Nandha College of Pharmacy, Erode 638 052, Tamil Nadu
  • Veluchamy Balakrishnan Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode 637 215, Tamil Nadu
Keywords: Alloxan, Antidiabetic, Glucose tolerance test, Hypoglycemic, Limonia elephantuma


The hypoglycemic activity of the aqueous leaf extract of Limonia elephantum was evaluated. The extract was administered orally 1,000 mg/kg to normal and alloxan-induced (55 mg/kg body weight, i.v) diabetic rats. The hypoglycemic effect of the extract was statistically significant with an oral dose of 1,000 mg/kg and was comparable to that of the effect produced by standard antidiabetic agent, metformin 1.5 mg/kg. The extract increased the glucose tolerance using oral glucose tolerance test.


Download data is not yet available.
743 Read

Author Biography

Veluchamy Balakrishnan, Department of Biotechnology, K. S. Rangasamy College of Technology, Tiruchengode 637 215, Tamil Nadu
Associate Professor


Anurag M, Sandeep A, Rajiv G, Manvi, Rajesh Kumar P, Ashish Kumar S. Effect of Feronia elephantum (Corr) Fruit pulp extract on indomethacin-induced gastric ulcer in albino rats. Tropical J Pharmaceut Res. 2009; 8: 509-14.

Deore SL, Khadabadi SS, Daulatkar VD, Deokate UA, Farooqui IU. Evaluation of hypoglycemic and antidiabetic activity of bark of Buteamonosperma. Phcog Mag. 2008; 4: 16-18.

Garg SC. Essential oil of Feronia elephantum Correa: A rich source of methyl chavicol. Indian Perfum. 2003; 47: 99-101.

Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethanopharmacol. 2002; 81: 81-100.

Gupta VC, Hussain SJ, Imam S. Important folk-medicinal plants and traditional knowledge of tribes of Aurangabad and Nasik forest divisions of Maharashtra (India). Hamdard Medic. 1997; 40: 59-61.

Hamdan N, Stephen JHA. Pharmacological characterization of the antihyperglycaemic properties of Tinospora crispa extract. J Ethanopharmacol. 1998; 62: 713.

Javed I, Mohammad A. Isolation of a flavonoid from Feronia limonia. J Saudi Chem Soc. 2009; 13: 29598.

Kamalakannan K, Balakrishnan V. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Limonia elephantum leaves. Bangladesh J Pharmacol. 2014; 9: 383-88.

Kamalakannan K, Balakrishnan V. Ethanobotanical studies on Achyranthes Aspera Linn. among the folk peoples of Tamil Nadu, South India. J Phytol. 2009; 1: 108-11.

Kanhiya M, Anurag M, Ashok Kumar V. Preliminary pharma-cognostical and phytochemical investigation on Feronia elephantum Corr. Fruit. J Pharm Res. 2008; 1: 44-47.

Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethanopharmacol. 2003; 84: 105-08.

Kirtikar KR, Basu BD. Feronia elephantum Corr. Indian medicinal plants. Vol. I. L.M.B. Publishers, 1995, pp 496-98.

Paget GE, Barnes JM. Toxicity tests. In: Evaluation of drug activities: Pharmacometrics. Laurence DR, Bacharach AL (ed). London, Academic Press, 1964, pp 135-66.

Patil KMM, Zambare GN, Khandelwal KR, Bodhankar SL. Hepatoprotective activity of aqueous extract of leaves of Feronia elephantum Correa. against thioacetamide and allyl alcohol intoxication in rats. Toxicol Int. 2004; 11: 69-74.

Prince PS, Kamalakannan N, Menon VP. Antidiabetic and hyperlipedemic effect of alcoholic Syzigium cumini seeds in alloxan induced diabetic albino rats. J Ethanopharmacol. 2004; 91: 209-13.

Sarah W, Gojka R, Green A, Sicree R, King H. Global prevalence of diabetes. Diabetes Care. 2004; 27: 1047-53.

Wells BG, Dipiro JT, Schwinghammer TL, Dispiro CV. Diabetes mellitus. In: Pharmacotherapy handbook. 7th ed. Singapore, McGraw Hill, 2009, pp 210-26.

How to Cite
Kamalakannan, K., and V. Balakrishnan. “Hypoglycemic Activity of Aqueous Leaf Extract of Limonia Elephantum in Alloxan-Induced Diabetic Rats”. Bangladesh Journal of Pharmacology, Vol. 9, no. 3, Sept. 2014, pp. 443-6, doi:10.3329/bjp.v9i3.19705.
Research Articles