Zostera noltii extract lowers blood glucose and restores vascular function in diabetic rats

  • M. Zeki Haznedaroglu Ege University, Faculty of Pharmacy, Department of Pharmaceutical Botany 35100, Bornova, Izmir
  • Goksel Gokce Ege University, Faculty of Pharmacy, Department of Pharmacology 35100, Bornova, Izmir, Turkey
Keywords: Zostera noltii, Diabetes, Antioxidant, Phenolic compounds, Endothelial dysfunction

Abstract

The antidiabetic effect of seagrass Zostera noltii extract was investigated through a crosstalk between its antioxidant and vasoprotective properties. The extract was orally administered to alloxan-diabetic rats (50, 150, 250 mg/kg body weight). Serum glucose was determined; liver and kidney functions, body weight, total leukocyte counts were measured; liver oxidative markers were assayed. Acetylcholine, phenylephrine and 5-HT responses were tested. eNOS levels and generation of ROS in aortic tissue were quantified. The extract of Z. noltii lowered blood glucose in all tested dose levels. Extract at a concentration of 50 mg/kg failed to preserve the levels of antioxidants and did not alter lipid peroxidation whereas higher doses improved liver oxidative status. Impaired acetylcholine relaxations, augmented phenylephrine and 5-HT contractions in alloxan-diabetic aortic rings were restored by Z. noltii treatment. This recovery was accompanied by increased eNOS synthesis and a reduction in ROS generation. The extract lowers blood glucose and prevents hyperglycemia-induced endothelial dysfunction in alloxan-diabetic rats.

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Author Biographies

M. Zeki Haznedaroglu, Ege University, Faculty of Pharmacy, Department of Pharmaceutical Botany 35100, Bornova, Izmir
Assistant Professor
Goksel Gokce, Ege University, Faculty of Pharmacy, Department of Pharmacology 35100, Bornova, Izmir, Turkey
Department of Pharmacology PhD Pharm. Researcher

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Published
2014-08-27
How to Cite
Haznedaroglu, M. Z., and G. Gokce. “Zostera Noltii Extract Lowers Blood Glucose and Restores Vascular Function in Diabetic Rats”. Bangladesh Journal of Pharmacology, Vol. 9, no. 3, Aug. 2014, pp. 389-97, doi:10.3329/bjp.v9i3.19437.
Section
Research Articles