A diterpenoid sugiol from Metasequoia glyptostroboides with α-glucosidase and tyrosinase inhibitory potential

  • Vivek K. Bajpai Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712 749
  • Sun Chul Kang Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk 712 714
Keywords: Metasequoia glyptostroboides, Sugiol, α-Glucosidase, Tyrosinase


Nowadays use of plant derived natural compounds have become a topic of increasing interest in food and medicine industries due to their multitude of biological and therapeutic properties. In this study, a diterpenoid compound sugiol, isolated from Metasequoia glyptostroboideswas evaluated for α-glucosidase and tyrosinase inhibitory efficacy in terms of its potent anti-diabetic and anti-melanogenesis potential, respectively. As a result, sugiol at the concentration range of (100-10,000 µg/mL) and (20-500 µg/mL) showed potent efficacy on inhibiting α-glucosidase and tyrosinase enzymes in vitro ranging from 12.34-63.47% and 28.22-67.43%, respectively. These findings confirm the therapeutic potential of diterpenoid compound sugiol from M. glyptostroboides as a novel candidate for using in food and medicine industry which may have practical potential to cure skin and diabetes mellitus type-2 related disorders.


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How to Cite
Bajpai, V., and S. C. Kang. “A Diterpenoid Sugiol from Metasequoia Glyptostroboides With α-Glucosidase and Tyrosinase Inhibitory Potential”. Bangladesh Journal of Pharmacology, Vol. 9, no. 3, July 2014, pp. 312-6, doi:10.3329/bjp.v9i3.19026.
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