Hepatoprotective effect of aqeous methanolic extract of Rumex dentatus in paracetamol induced hepatotoxicity in mice

  • Mohammad Saleem College of Pharmacy, GC University Faisalabad, Pakistan
  • Bilal Ahmed College of Pharmacy, GC university Faisalabad
  • Mahrukh Karim College of Pharmacy, GC University Faisalabad
  • Shahzad Ahmed Draxel University College of Medicines, Philadelphia, USA
  • Mobasher Ahmad University College of Pharmacy, University of The Punjab Lahore
  • M. Imran Qadir Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan
  • Nawazish-i-Husain Syed University College of Pharmacy, University of The Punjab Lahore, Pakistan
Keywords: Hepatoprotective, HPLC, Paracetamol, Rumex dentatus

Abstract

Rumex dentatus is well known plant of Polygonaceae family which is widely used in traditional medicine to treat gastrointestinal tract. R. dentatus at doses 250 and 500 mg/kg significance decreased (p<0.001) the elevated level of ALT, AST, ALP and bilirubin induced by paracetamol and results are comparable (p<0.001) with silymarin. The results were supported by histopathological investigations, phytochemical screening and detection of hepatoprotective active constituents e.g quercetin, kaempferol, myricetin by HPLC. So, it is concluded that R. dentatus has hepatoprotective effect against paracetamol liver damage in mice.

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Published
2014-07-13
How to Cite
Saleem, M., B. Ahmed, M. Karim, S. Ahmed, M. Ahmad, M. I. Qadir, and N.- i-H. Syed. “Hepatoprotective Effect of Aqeous Methanolic Extract of Rumex Dentatus in Paracetamol Induced Hepatotoxicity in Mice”. Bangladesh Journal of Pharmacology, Vol. 9, no. 3, July 2014, pp. 284-9, doi:10.3329/bjp.v9i3.18874.
Section
Research Articles