Stereospermum tetragonam as an antidiabetic agent by activating PPARγ and GLUT4

Authors

  • Bino Kingsley School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu
  • K. P. Arun School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401
  • Stalin Selvaraj School of chemical & Biotechnology, SASTRA University, Thanjavur 613 401.TamilNadu
  • Brindha Pemiah School of chemical & Biotechnology, SASTRA University, Thanjavur 613 401

DOI:

https://doi.org/10.3329/bjp.v9i2.18488

Keywords:

Diabetes, GLUT-4, in silico, PPARγ, Stereospermum tetragonam

Abstract

Present study evaluates the anti-diabetic activity of S. tetragonam LC-MS/MS experiments showed the presence of two novel molecules C1 and C2, which were further taken for in silico study against PPARγ. Cell culture studies with A431 cells in the presence of crude aqueous extract showed the elevated level of PPARγ and GLUT4 and also confirmed using in silico studies. Thus, the present study proves the mecode of action of S. tetragonam as an antidiabetic drug.

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Author Biographies

Bino Kingsley, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu

Research Scholar

K. P. Arun, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401

Research Scholar

Stalin Selvaraj, School of chemical & Biotechnology, SASTRA University, Thanjavur 613 401.TamilNadu

Professor

Brindha Pemiah, School of chemical & Biotechnology, SASTRA University, Thanjavur 613 401

Associate Professor & Coordinator

References

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Published

2014-06-26

How to Cite

Kingsley, B., K. P. Arun, S. Selvaraj, and B. Pemiah. “Stereospermum Tetragonam As an Antidiabetic Agent by Activating PPARγ and GLUT4”. Bangladesh Journal of Pharmacology, vol. 9, no. 2, June 2014, pp. 250-6, doi:10.3329/bjp.v9i2.18488.

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Section

Research Articles