Stereospermum tetragonam as an antidiabetic agent by activating PPAR? and GLUT4

Bino Kingsley, Arun KP, Stalin Selvaraj, Brindha Pemiah

Abstract

Present study evaluates the anti-diabetic activity of S. tetragonam LC-MSMS experiments showed the presence of two novel molecules C1 and C2, which were further taken for in silico study against PPAR?. Cell culture studies with A431 cells in the presence of crude aqueous extract showed the elevated level of PPAR? and GLUT4 and also confirmed using in silico studies. Thus, the present study proves the mecode of action of S. tetragonam as an antidiabetic drug.

 

Keywords

Stereospermum tetragonam; Diabetes; PPAR?; GLUT-4; in silico studies

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References

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DOI: http://dx.doi.org/10.3329/bjp.v9i2.18488

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Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is a single-blinded peer-reviewed, video component, open access official publication of the Bangladesh Pharmacological Society (BDPS). eISSN: 1991-0088. For contact: Editor-In-Chief