Hepatoprotective activity of Thymus linearis against paracetamol and carbon tetrachloride-induced hepatotoxicity in albino mice

Authors

  • - Alamgeer Faculty of Pharmacy, University of Sargodha, Sargodha
  • Mehwish Nawaz Faculty of Pharmacy, University of Sargodha, Sargodha
  • Taseer Ahmad Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad
  • Muhammad Naveed Mushtaq Faculty of Pharmacy, University of Sargodha, Sargodha
  • Asma Batool Faculty of Pharmacy, University of Sargodha, Sargodha

DOI:

https://doi.org/10.3329/bjp.v9i2.18329

Keywords:

Anti-oxidant, Hepatoprotective, Thymus linearis

Abstract

In the present study, the hepatoprotective activity of aqueous and ether extracts of Thymus linearis (250 and 500 mg/kg orally) was evaluated against carbon tetrachloride- and paracetamol-induced hepatic damage in mice. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) were assessed. Antioxidant activity of both the extracts was also determined using 1-1-diphenyl-2-picryl hydrazine (DPPH) scavenging method. The results indicated that both the extracts significantly produce a dose dependent reduction in serum levels of ALT, AST, ALP when compared to carbon tetrachloride-and paracetamol-treated groups. The maximum effect in all the parameters was observed at a dose of 500 mg/kg. The extracts also demonstrated a significant antioxidant activity. LD50 of both extracts was found to be a 1050 and 900 mg/kg respectively. It is conceivable that the hepatoprotective activity of T. linearis might be due to the presence of certain pharmacologically active compounds.

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Author Biographies

- Alamgeer, Faculty of Pharmacy, University of Sargodha, Sargodha

Assistant Professor

Mehwish Nawaz, Faculty of Pharmacy, University of Sargodha, Sargodha

Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan.

Taseer Ahmad, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad

Lecturer

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Additional Files

Published

2014-05-17

How to Cite

Alamgeer, .-., M. Nawaz, T. Ahmad, M. N. Mushtaq, and A. Batool. “Hepatoprotective Activity of Thymus Linearis Against Paracetamol and Carbon Tetrachloride-Induced Hepatotoxicity in Albino Mice”. Bangladesh Journal of Pharmacology, vol. 9, no. 2, May 2014, pp. 230-4, doi:10.3329/bjp.v9i2.18329.

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Section

Research Articles