Arabinosyl transferase inhibitor design against Mycobacterium tuberculosis using ligand based drug design approach

Authors

  • Bhaskor Kolita Centre for Bioinformatics Studies, Dibrugarh University, Dibrugarh, Assam
  • Dhrubajyoti Gogoi DBT-Bioinformatics Infrastructure Facility, Biotechnology Division, North East Institute of Science and Technology (Formerly Regional Research Laboratory), CSIR, Government of India, Jorhat, Assam
  • Partha Pratim Dutta Natural Product Chemistry Division, North East Institute of Science and Technology (Formerly Regional Research Laboratory), CSIR, Government of India, Jorhat, Assam
  • Manobjyoti Bordoloi Natural Product Chemistry Division, North East Institute of Science and Technology (Formerly Regional Research Laboratory), CSIR, Government of India, Jorhat, Assam
  • Rajib Lochan Bezbaruah DBT-Bioinformatics Infrastructure Facility, Biotechnology Division, North East Institute of Science and Technology (Formerly Regional Research Laboratory), CSIR, Government of India, Jorhat, Assam

DOI:

https://doi.org/10.3329/bjp.v9i2.18270

Keywords:

Arbinosyl transferase, Docking, Ethambutol, Mycobacterium tuberculosis

Abstract

Antibiotic resistance is a major challenge to combat tuberculosis. Several reports of antibiotic resistance strains of Mycobacterium tuberculosis is strongly demanding the need of new and alternative antibiotics for its inhibition. Therefore, current investigation is an attempt to screen few lead molecules for the inhibition of arbinosyl transferase enzyme of M. tuberculosis. The inhibition of this enzyme is an established target of many antibiotics especially ethambutol. Herein, we have considered the structure of ethambutol as a starting point to screen active compound then ethambutol. Similar compounds were searched in chemical database and six compounds were identified and considered as selective arbinosyl transferase inhibitor based on physiochemical properties, bioactivity and ADME with least docking score. The compounds viz. ZINC00388344, ZINC003884, Chemspider2057082, ZINC-00388344, ZINC0038846, Chemspider2057082, Etha17 (analog) and Etha10 (analog) were finally screened and recommended for in vitro investigation.

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Additional Files

Published

2014-05-14

How to Cite

Kolita, B., D. Gogoi, P. P. Dutta, M. Bordoloi, and R. L. Bezbaruah. “Arabinosyl Transferase Inhibitor Design Against Mycobacterium Tuberculosis Using Ligand Based Drug Design Approach”. Bangladesh Journal of Pharmacology, vol. 9, no. 2, May 2014, pp. 225-9, doi:10.3329/bjp.v9i2.18270.

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Section

Research Articles