Hepatoprotective activity of aqueous-methanolic extract of Suaeda fruticosa in paracetamol-induced hepatotoxicity in rabbits

Authors

  • Jalil Ur Rehman University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur
  • Najam Us Saqib Federal Inspector of drugs, Cabinet Division, Government of Pakistan
  • Naveed Akhtar University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur
  • Muhammad Jamshaid Faculty of Pharmacy, University of Central Punjab, Johar Town Lahore
  • Hafiz Muhammad Asif Department of Eastern Medicine & Surgery, Faculty of Medical & Health Sciences, The University of Poonch, Rawalakot, AJ& K
  • Sabira Sultana University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur
  • Riaz Ur Rehman University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur

DOI:

https://doi.org/10.3329/bjp.v8i4.16631

Keywords:

Suaeda fruticosa, Hepatoprotective, Paracetamol, Sylamrin, Histopathology

Abstract

In the present study, we evaluated the protective effects of the aqueous-methanolic extract of Suaeda fruticosa (500 mg/kg and 750 mg/kg b.w., p.o) against paracetamol-induced hepatotoxicity in rabbits.  Silymarin 100 mg/kg, p.o. was served as standard. The degree of protection was determined by measuring the levels of biochemical marker such as SGOT, SGPT, ALP and bilirubin (total). The results showed that extract of S. fruticosa significantly (p<0.05) decreased the paracetamol-induced increased levels of liver enzymes and total bilirubin in a dose dependent manner. Histopathological studies also revealed the hepatoprotective effects of S. fruticosa. It is concluded that the aqueous-methanolic extract of S. fruticosa possesses hepatoprotective activity. 

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Published

2013-11-13

How to Cite

Rehman, J. U., N. U. Saqib, N. Akhtar, M. Jamshaid, H. M. Asif, S. Sultana, and R. U. Rehman. “Hepatoprotective Activity of Aqueous-Methanolic Extract of Suaeda Fruticosa in Paracetamol-Induced Hepatotoxicity in Rabbits”. Bangladesh Journal of Pharmacology, vol. 8, no. 4, Nov. 2013, pp. 378-81, doi:10.3329/bjp.v8i4.16631.

Issue

Vol. 8 No. 4 (2013)

Section

Research Articles

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