Elemental compositions and antianemic property of Harungana madagascariensis stem bark
Keywords:
Antienemic, Harungana madagascariensis, X-ray fluorescence, Stem barkAbstract
The concentrations of 15 elements and heavy metals in the stem bark of Harungana madagascariensis were determined using an energy-dispersive X-ray fluorescence (EDXRF) spectrometer. The antianemic activity was done using the changes in hematological parameters (PCV, RBC and hemoglobin) influenced by phenylhydrazine HCL (80 mg/kg) and malaria parasites-induced anemia. Results show Cd, Ni, Mo, Cr and Br were in the range of 0.02–0.9 mg/g, while Pb, Zn, Fe, Cu and hemoglobin were in the range of 1.5–7.2 mg/g. The elements with very high concentration were Ca, K, Sr, Mn and Cl and were in the range of 10.5–774.3 mg/g. Remarkable antianemic activity was obtained with PCV of 40–48%, RBC count of 81-155 x 104 and hemoglobin value of 57-66 g/dL after treatment; compared with 30% PCV, 67 x 104 RBC count and 36.5 g/dL hemoglobin value obtained for the untreated control animals. Our results suggest that H. madagascariensis stem bark extract constituents exhibit antianemic activity.
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