Antihyperglycemic activity of Trichosanthes tricuspidata root extract
To evaluate the anti-diabetic activity of ethanolic extract of Trichosanthes tricuspidata root in alloxan induced diabetic rats and to perform the phytochemical screening. The extraction, preliminary phytochemical screening, anti-diabetic activity in alloxan induced diabetic rats by oral administration of extract (200 and 400 mg/kg b.w.), the blood glucose level and biochemical parameters like cholesterol, triglyceride, serum protein, SGPT, SGOT, and ALP were estimated. Phytochemical studies shows the presence of carbohy-drates, proteins, glycosides and terpenoids and the ethanolic extract of T. tricuspidata root significantly lowered the blood sugar level. The above findings justified the traditional claim of anti-diabetic activity in this plant.
Alamgeer, Rashid M, Bashir S, Mushtaq MN, Khan HU, Malik MNH, Qayyum A, Shafeeq ur Rahaman M. Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits. Bangladesh J Pharmacol. 2013; 8: 186-93.
Arvind K, Pradeep R, Deepa R, Mohan V. Diabetes and coronary artery diseases. Indian J Med Res. 2002; 16: 163-76.
Bandara T, Rokeya B, Khan S, Ali L, Ekanayake S, Jansz ER, Balasubramanium K. Effects of Gymnema lactiferum leaves on glycemic and lipidemic status in type 2 diabetes subjects. Bangladesh J Pharmacol. 2009; 4: 92-95.
Bhavsar C, Talele GS. Potential anti-diabetic activity of Bombax ceiba. Bangladesh J Pharmacol. 2013; 8: 102-06.
Bhowmik A, Khan LA, Akhter M, Rokeya B. Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats. Bangladesh J Pharmacol. 2009; 4: 110-14.
Chakravarthy BK, Gupta S, Gode KD. Functional beta cell regeneration in the islets of pancreas in alloxan induced diabetic rats by (-)-epicatechin. Life Sci. 1982; 31: 2693-97.
Chopra RN, Nayar SN, Chopra TC. Glossary of Indian medicinal plants. New Delhi, Council of Scientific and Industrial Research, 1956.
Felig P, Marliss E, Ohman J, Cahil Jr JF, Plamaaminoacinos level in diabetic ketoacidosis. Diabetes 1970; 19: 727.
Gaur RD. Flora of the District Garhwal North West Himalaya. Srinagar, Uttarakhand (India). Transmedia Publishers. 1999.
Ghosh S, Suryawanshi SA. Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J Exp Biol. 2001; 39: 748-59.
Hakkim FL, Girija S, Kumar RS, Jalaludeen MD. Effect of aqueous and ethanol extracts of Cassia auriculata L. flowers on diabetes using alloxan-induced diabetic rats. Int J Diab Metabol. 2007; 15: 100-06.
Halberstam M, Cohen N, Shlimovich P, Rossetti L, Shamoon H. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996; 45: 659-66.
Harborne JB. Phytochemical methods: A guide to modern techniques of plant analysis. London, Chapman and Hall, 2005, pp 182-89.
Henry RR. Resurrecting the beta cell in type 2 diabetes: Clinical impact of therapies directed at beta-cell preservation. Medscape Education, 2006.
Kanchanapoom T, Ryoji K, Yamasaki K. Cucurbitane, hexanorcucurbitane and octanorcucurbitane glycosides from fruits of Trichosanthes tricuspidata. Phytochemistry 2002; 59: 215-28.
Kaneda M, Uchikoba T. Protease from the sarcocarp of Trichosanthes bracteata. Phytochemistry 1994; 35: 583-86.
Kasai R, Sasaki A, Hashimoto.T, Kaneko.T, Ohtani K, Yamasaki K. Cycloartane glycosides from Trichosanthes tricuspidata. Phytochemistry 1999; 51: 803-08.
Khanam M, Dewan ZF. Effects of the crude and the n-hexane extract of Nigella sativa Linn. (kalajira) upon diabetic rats. Bangladesh J Pharmacol. 2009; 4: 17-20.
Kitajima J, Mukai A, Masuda Y, Tanaka Y. Studies on the constituents of Trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voight. Yakugaku Zasshi 1989; 109: 265-70.
Kokate CK. Practical pharmacognosy. 1st ed. New Delhi, Vallabh Prakashan, 1994.
Mai le P, Guenard D, Franck M, Van TM, Gaspard C, Sevenet T. New cytotoxic cucurbitacins from the pericarps of Trichosanthes tricuspidata fruits. Nat Prod Lett. 1994; 16: 15-19.
Marles RJ, Farnsworth NR. Plants as sources of antidiabetic agents. Econ Med Plant Res. 1994; 6: 149-87.
Mohamed PA. Isolation of Trichotetrol: A new tetrahydroxy pentacyclic triterpene from Trichosanthes bracteata (Cucurbitaceae). Linn.,Voight. Syn. T. palmata (Roxb.). Curr Sci. 1974; 43: 116.
Pattanayak S, Nayak SS, Panda D, Shende V. Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats. Bangladesh J Pharmacol. 2009; 4: 131-35.
Peach K. Modern Methods of plant analysis. Vol 4. Springer-Verlag, 1955.
Persinos GJ, Quimby MW. Nigerian plants III: Phytochemical screening for alkaloids, saponins and tannins. J Pharm Sci. 1967; 56: 1512.
Porchezhian E, Ansari SH, Shreedharan NKK. Antihyperglycemic activity of Euphrasia officinale leaves. Fitoterapia 2000; 71: 522-26.
Prajapati DD, Patel NM, Savadi RV, Akki KS, Mruthunjaya K. Alleviation of alloxan-induced diabetes and its complications in rats by Actinodaphne hookeri leaf extract. Bangladesh J Pharmacol. 2008; 3: 102-06.
Ravi S, Sadashiva CT, Tamizmani T, Balasubramanian T, Rupeshkumar M, Balachandran I. In vitro glucose uptake by isolated rat hemi-diaphragm study of Aegle marmelos Correa root. Bangladesh J Pharmacol. 2009; 4: 65-68.
Saha BK, Bhuiyan MNH, Mazumder Haque KKMF. Hypoglycemic activity of Lagerstroemia speciosa L. extract on streptozotocin-induced diabetic rat: Underlying mechanism of action. Bangladesh J Pharmacol. 2009; 4: 79-83.
Sen S, De B, Devanna N, Chakraborty R. Hypoglycaemic and hypolipidemic effect of Meyna spinosa leaves in high fat diet-alloxan induced type 2 diabetic rats. Bangladesh J Pharmacol. 2013; 8: 181-85.
Stanely P, Prince M, Menon V. Hypoglycemic and other related actions of Tinospora cordifolia roots in alloxan induced diabetic rats. J Ethnopharmacol. 1999; 70: 9-15.
Subbiah R, Kasiappan R, Karuran S, Sorimuthu S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol. 2006; 33: 232-37.
Sumana G, Suryawanshi SA, Effect of vinka rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J Exp Biol. 2001; 39: 748-59.
Suresh J, Ramachandra S, Kharya MD. Influence of itraconazole on antidiabetic effect of thiazolidinedione in diabetic rats. Int J Pharmacy Pharmaceut Sci. 2009; 1: 119-24.
Szkudelski T. The mechanism of alloxan and streptozotocin action in B-cells of the rat pancreas. Physiol Res. 2001; 50: 536.
Tatiya AU, Puranik PM, Surana SJ, Patil YS, Mutha RE. Evaluation of hypolipidemic, antidiabetic and anti-oxidant activity of Eulophia herbacea tubers. Bangladesh J Pharmacol. 2013; 8: 269-75.
Copyright (c) 2013 Srinivasan Kulandaivel, Pawan Bajpai, Thangavel Sivakumar
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).