Antihyperlipidemic and renoprotective activities of methanolic extract of Canscora decussata extract in alloxan-induced diabetic rabbits

  • Nadeem Irshad Hamdard Institute of Pharmaceutical Sciences, Islamabad Campus, Islamabad 44000,
  • Muhammad Shoaib Akhtar Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100,
  • Yousaf Kamal Hamdard Institute of Pharmaceutical Sciences, Islamabad Campus, Islamabad- 44000
  • Muhammad Imran Qayyum Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100
  • Abdul Malik Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100
  • Rashid Hussain Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100
Keywords: Alloxan, Atherogenic index, Canscora decussata, Coronary risk index, Antihyperlipidemic, Renoprotective


The current study was designed to evaluate the hypolipidemic and renopro-tective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 and 600 mg/kg doses and another group got pioglitazone (3 mg/kg) for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, albumin, globulin and total proteins were estimated by using commercially available kits. The results showed that extract significantly (p<0.01) decreased the raised parameters including triglyceride, total cholesterol and LDL-cholesterol, atherogenic index, Coronary risk index up to normal values compared to diabetic rabbits. However, it significantly increased HDL-cholesterol, albumin, globulin and total protein levels. Therefore, it is suggested that methanolic extract of C. decussata exerts hypolipidemic and renoprotective effects in the alloxan-induced diabetic rabbits.


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Author Biographies

Nadeem Irshad, Hamdard Institute of Pharmaceutical Sciences, Islamabad Campus, Islamabad 44000,
Muhammad Shoaib Akhtar, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha 40100,
Yousaf Kamal, Hamdard Institute of Pharmaceutical Sciences, Islamabad Campus, Islamabad- 44000
Assistant Professor
Muhammad Imran Qayyum, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100
Research Scholar
Abdul Malik, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100
Rashid Hussain, Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha-40100


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How to Cite
Irshad, N., M. S. Akhtar, Y. Kamal, M. I. Qayyum, A. Malik, and R. Hussain. “Antihyperlipidemic and Renoprotective Activities of Methanolic Extract of Canscora Decussata Extract in Alloxan-Induced Diabetic Rabbits”. Bangladesh Journal of Pharmacology, Vol. 8, no. 3, July 2013, pp. 323-7, doi:10.3329/bjp.v8i3.15506.
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