Hepatoprotective potential of Convolvulus arvensis against paracetamol-induced hepatotoxicity

  • Mohsin Ali College of Pharmacy, GC University, Faisalabad
  • M. Imran Qadir College of Pharmacy, GC University, Faisalabad
  • Mohammad Saleem College of Pharmacy, GC University, Faisalabad
  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahauddin Zakariya University, Multan
  • Humaira Gul College of Pharmacy, GC University, Faisalabad
  • Liaqat Hussain College of Pharmacy, GC University, Faisalabad
  • Bashir Ahmad Faculty of Pharmacy, Bahauddin Zakariya University, Multan
Keywords: Hepatoprotective, Serum enzymes, Hepatotoxicity, Paracetamol


Convolvulus arvensis is traditionally used as laxative. Its decoction is used in cough, flu, jaundice and in skin diseases. It is also used to treat the painful joints, inflammation and swelling. The current study was conducted to determine its hepatoprotective activity. The results showed that extract of C. arvensis (200 mg/kg and 500 mg/kg) produced significant (p<0.05) decrease in paracetamol induced increased levels of liver enzymes and total bilirubin. Histopathological investigation and detection of active constituent, qurecetin by HPLC also supported the results. So the current study showed that ethanolic extract of C. arvensis possess hepatoprotective activity.


Download data is not yet available.
883 Read


Adewusi AE, Afolayan JA. A review of natural products with hepatoprotectiveactivity. J Medcinal Plant Res. 2010; 4, 1318-34.

Ahmad M, Mahmood Q, Gulzar K, Akhtar MS, Saleem M, Qadir MI. Antihyperlipidaemic and hepatoprotective activity of Dodonaea viscosa leaves extracts in alloxan-induced diabetic rabbits (Oryctolagus cuniculus). Pak Vet J. 2012; 32: 50-54.

Akhtar MS, Asjad HMM, Bashir S, Malik A, Khalid R, Gulzar F, Irshad N. Evaluation of antioxidant and hepatoprotective effects of Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala (KGA). Bangladesh J Pharmacol. 2013; 8: 44-48.

Atta AH, Mohamed NH, Naser SM, Mouneir SM. Phytochemical and pharmacological studies on Convolvulus fatmensis Ktze. J Natural Rem. 2007; 7: 109-19.

Bag AK, Mumtaz SMF. Hepatoprotective and nephroprotective activity of hydroalcoholic extract OfIpomoea staphylina leaves. Bangladesh J Pharmacol. 2013; 8: 263-68.

Balamurugan G, Muthusamy P. Observation of the hepatoprotective and antioxidant activities of Trianthema decandra Linn. (Vallai sharunnai) roots on carbon tetrachloride-treated rats. Bangladesh J Pharmacol. 2008; 3: 83-89.

Elzaawely AA, Tawata S. Antioxident Activity of Phenolic Rich Fraction obtained from Convolvulus arvensis L. leaves grown in Egypt. Asian J Crop Sci.2012; 4, 32-40.

Girish C, Koner CB, Jayanthi S, Rao RK, Rajesh B, Pradhan CS. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundamen Clin Pharmacol. 2009; 23, 735-45.

Hegde K, Joshi AB. Hepatoprotective and antioxidant effect of Carissa spinarum root extract against CCl4 and paracetamol-induced hepatic damage in rats. Bangladesh J Pharmacol. 2010; 5: 73-76.

Iqbal H, Sher Z, Khan UZ. Medicinal plants from salt range Pinddadan Khan, District Jehlum, Punjab, Pakistan. J Medcinal Plant Res. 2011; 5: 2157-68.

Kaur M, Kalia A. Convolvulus arvensis: A useful weed. Intern J Pharm and Pharmaceut Sci. 2012; 4: 38-40.

Khadeem JE. Identification of quercetin in Echinopstenuisectus family compositeae. AJPS.2007; 4: 64-80.

Khan I, Singh V, Chaudhary AK. Hepatoprotective activity of Pinus roxburghii Sarg. wood oil against carbon tetrachloride- and ethanol-induced hepatotoxicity. 2012; 7: 94-99.

Kumar HC, Ramesh A, Kumar SN, Ishaq MB. A review on hepatoprotectiveactivity of medicinal plants. IJPSR. 2011; 2: 501-15.

Mungole JA, Awati R, Chaturvedi A, Zanwar P. Preliminary phytochemical screening of Ipomoea obscura (L): A hepatoprotective medicinal plant. Inter J Pharm Tech Res. 2010; 2: 2307-12.

Pavanato A, Tuñón MJ, Sánchez CS, Marroni CA, Llesuy S, González GJ, Marroni N. 2003. Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. Dig Dis Sci. 2008; 48: 824-29.

Sabir MS, Rocha TBJ. Water-extractable phytochemicals from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice. Food Chem. 2008; 111: 845-51.

Saboo SS, Tapadiya G, Farooqui IA, Khadabadi SS. Free radical scavenging, in vivo antioxidant and hepatoprotective activity of folk medicine Trichodesma sedgwickianum. Bangladesh J Pharmacol. 2013; 8: 58-64.

Sadeque MZ, Begum ZA. Protective effect of dried fruits of Carica papaya on hepatotoxicity in rat. Bangladesh J Pharmacol. 2010; 5: 48-50.

Shanmugasundaram P, Venkataraman S. Hepatoprotective and antioxidant effect of Hygrophila auriculata (K. Schum) Heine Acanthacaea root extract. J Ethnopharmacol. 2006; 104: 124-28.

Thakare SP, Jain HN, Patil SD, Upadhyay UM. Hepatoprotective effect of Cocculus hirsutus on bile duct ligation-induced liver fibrosis in Albino Wistar rats. Bangladesh J Pharmacol. 2009; 4: 126-30.

Thakral J, Borar S, Kalia JAR. Antioxidant potential fractionation from methanol extract of aerial parts of Convolvulus arvensis Linn. (Convolvulaceae). Inter J Pharma Sci Drug Res. 2010; 2: 219-23.

How to Cite
Ali, M., M. I. Qadir, M. Saleem, K. H. Janbaz, H. Gul, L. Hussain, and B. Ahmad. “Hepatoprotective Potential of Convolvulus Arvensis Against Paracetamol-Induced Hepatotoxicity”. Bangladesh Journal of Pharmacology, Vol. 8, no. 3, July 2013, pp. 300-4, doi:10.3329/bjp.v8i3.15165.
Research Articles