Hepatoprotective potential of Convolvulus arvensis against paracetamol-induced hepatotoxicity

  • Mohsin Ali College of Pharmacy, GC University, Faisalabad
  • M. Imran Qadir College of Pharmacy, GC University, Faisalabad
  • Mohammad Saleem College of Pharmacy, GC University, Faisalabad
  • Khalid Hussain Janbaz Faculty of Pharmacy, Bahauddin Zakariya University, Multan
  • Humaira Gul College of Pharmacy, GC University, Faisalabad
  • Liaqat Hussain College of Pharmacy, GC University, Faisalabad
  • Bashir Ahmad Faculty of Pharmacy, Bahauddin Zakariya University, Multan
Keywords: Hepatoprotective, Serum enzymes, Hepatotoxicity, Paracetamol

Abstract

Convolvulus arvensis is traditionally used as laxative. Its decoction is used in cough, flu, jaundice and in skin diseases. It is also used to treat the painful joints, inflammation and swelling. The current study was conducted to determine its hepatoprotective activity. The results showed that extract of C. arvensis (200 mg/kg and 500 mg/kg) produced significant (p<0.05) decrease in paracetamol induced increased levels of liver enzymes and total bilirubin. Histopathological investigation and detection of active constituent, qurecetin by HPLC also supported the results. So the current study showed that ethanolic extract of C. arvensis possess hepatoprotective activity.

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Published
2013-07-08
How to Cite
Ali, M., M. I. Qadir, M. Saleem, K. H. Janbaz, H. Gul, L. Hussain, and B. Ahmad. “Hepatoprotective Potential of Convolvulus Arvensis Against Paracetamol-Induced Hepatotoxicity”. Bangladesh Journal of Pharmacology, Vol. 8, no. 3, July 2013, pp. 300-4, doi:10.3329/bjp.v8i3.15165.
Section
Research Articles