Studies on bronchodilator and cardiac stimulant activities of Urginea indica

  • Samra Bashir Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi
  • Saima Abbas Faculty of Pharmacy, Bahauddin Zakariya University, Multan
  • Aslam Khan Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi
  • Anwar Hassan Gilani
Keywords: Anticholinergic, Bronchodilator, Ca2 antagonist, Cardiac-stimulant, Urginea indica

Abstract

This study was designed to evaluate bronchodilator and cardio-tonic effects of Urginea indica to provide rational for these medicinal uses. U. indica bulb extract was studied on rabbit tracheal and guinea-pig atrial preparations mounted in tissue baths under simulated physiological conditions. U. indica inhibited carbachol (1 µM) and K+ (80 mM)-induced contractions in rabbit trachea, similar to dicyclomine, suggesting the presence of anticholinergic and calcium channel blocking (CCB) mechanisms in U. indica. Anticholinergic and CCB effects of U. indica were respectively confirmed when it shifted the carbachol and Ca2+ concentration-response curves rightwards, similar to dicyclomine. U. indica (0.01-1 mg/mL) increased force of guinea-pig atrial contractions without significantly affecting the rate. These data, indicating that U. indica possesses the bronchodilator activity possibly mediated through a combination of anticholinergic and Ca2+ antagonist mechanisms together with selective positive inotropic effect, provide rational for medicinal applications of U. indica in airways and cardiac disorders.

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Author Biography

Samra Bashir, Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi
Assistant Professor

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Published
2013-05-20
How to Cite
Bashir, S., S. Abbas, A. Khan, and A. Gilani. “Studies on Bronchodilator and Cardiac Stimulant Activities of Urginea Indica”. Bangladesh Journal of Pharmacology, Vol. 8, no. 3, May 2013, pp. 249-54, doi:10.3329/bjp.v8i3.14825.
Section
Research Articles